Stability of influenza vaccine coated onto microneedles.

Biomaterials
Hyo-Jick ChoiMark R Prausnitz

Abstract

A microneedle patch coated with vaccine simplifies vaccination by using a patch-based delivery method and targets vaccination to the skin for superior immunogenicity compared to intramuscular injection. Previous studies of microneedles have demonstrated effective vaccination using freshly prepared microneedles, but the issue of long-term vaccine stability has received only limited attention. Here, we studied the long-term stability of microneedles coated with whole inactivated influenza vaccine guided by the hypothesis that crystallization and phase separation of the microneedle coating matrix damages influenza vaccine coated onto microneedles. In vitro studies showed that the vaccine lost stability as measured by hemagglutination activity in proportion to the degree of coating matrix crystallization and phase separation. Transmission electron microscopy similarly showed damaged morphology of the inactivated virus vaccine associated with crystallization. In vivo assessment of immune response and protective efficacy in mice further showed reduced vaccine immunogenicity after influenza vaccination using microneedles with crystallized or phase-separated coatings. This work shows that crystallization and phase separation of the dri...Continue Reading

References

Oct 1, 1986·Chemical & Pharmaceutical Bulletin·E FukuokaS Yamamura
Apr 1, 1984·The Journal of General Virology·R W RuigrokJ E Mellema
Jan 1, 1997·Journal of Pharmaceutical Sciences·B C Hancock, G Zografi
Mar 4, 1999·International Journal of Pharmaceutics·D Q CraigM L Hopton
Jun 4, 2004·Journal of Pharmaceutical Sciences·Yuh-Fun MaaDexiang Chen
Nov 5, 2004·The New England Journal of Medicine·Richard T KenneyGregory M Glenn
Dec 16, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Harvinder S Gill, Mark R Prausnitz
Mar 27, 2007·Pharmaceutical Research·Harvinder S Gill, Mark R Prausnitz
Nov 23, 2007·Journal of Virology·Fu-Shi QuanSang-Moo Kang
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Qiyun ZhuRichard W Compans
Jul 7, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xianfeng ChenMark A F Kendall
Oct 21, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yeu-Chun KimMark R Prausnitz
Apr 14, 2010·Pharmaceutical Research·Yeu-Chun KimMark R Prausnitz
Feb 1, 2011·Vaccine·Yasuhiro HiraishiMark R Prausnitz
May 24, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Jun 21, 2011·The Journal of Infectious Diseases·Dimitrios G KoutsonanosIoanna Skountzou

❮ Previous
Next ❯

Citations

Oct 9, 2013·Archives of Pharmacal Research·Hyo-Jick ChoiCarlo D Montemagno
Sep 21, 2013·Biomaterials·Jacob W CoffeyMark A F Kendall
Dec 10, 2013·Nature Biotechnology·Peter C DeMuthDarrell J Irvine
Jul 17, 2013·Advanced Drug Delivery Reviews·Eric Nuxoll
Feb 14, 2014·Expert Opinion on Drug Delivery·Harvinder S GillRichard W Compans
Nov 22, 2012·Journal of Drug Targeting·Jeong Woo LeeJung-Hwan Park
Dec 19, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyo-Jick ChoiMark R Prausnitz
May 12, 2012·Advanced Drug Delivery Reviews·Yeu-Chun KimMark R Prausnitz
Nov 26, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaya Arya, Mark R Prausnitz
Dec 2, 2015·Pharmaceutical Research·Leonard Y ChuMark R Prausnitz
Jan 27, 2015·International Journal of Pharmaceutics·Md Jasim UddinDennis Douroumis
Oct 19, 2016·Human Vaccines & Immunotherapeutics·Sarah MarshallAnne C Moore
May 18, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Tuan-Mazlelaa Tuan-MahmoodRyan F Donnelly
Aug 16, 2016·Drug Delivery and Translational Research·Seong-Jin KimYeu-Chun Kim
Sep 4, 2016·Expert Opinion on Drug Delivery·Marija ZaricLinda Sylvia Klavinskis
Jan 5, 2017·Scientific Reports·Fu-Shi QuanHyo-Jick Choi
Jan 30, 2018·Frontiers in Immunology·Anne Marit de GrootKoen van der Maaden
Jan 14, 2018·Scientific Reports·Theresa K ReschBaoming Jiang
Feb 5, 2019·Current Drug Delivery·Heather A E BensonMichael S Roberts
Feb 23, 2020·Journal of Clinical Medicine·Rezvan JamaledinPaolo Antonio Netti
Jun 30, 2019·Bioengineering & Translational Medicine·Michelle E TurveyPaula T Hammond
May 23, 2019·Scientific Reports·Vincent LeungCarlos D M Filipe
Aug 11, 2018·Archives of Pharmacal Research·Bahman HomayunHyo-Jick Choi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Anto VrdoljakAnne C Moore
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Yeu-Chun KimMark R Prausnitz
Proceedings of the National Academy of Sciences of the United States of America
Qiyun ZhuRichard W Compans
© 2022 Meta ULC. All rights reserved