Stability of oxyhemoglobin affinity in patients with obstructive sleep apnea-hypopnea syndrome without daytime hypoxemia

Journal of Applied Physiology
Didier ClauseGiuseppe Liistro

Abstract

A decrease in hemoglobin affinity for oxygen is considered an adaptive mechanism against tissue hypoxia. Obstructive sleep apnea-hypopnea syndrome (OSAHS) is characterized by recurrent episodes of apnea and hypopnea resulting in arterial oxygen desaturations during sleep. Maillard et al. (10) observed a right shift of the oxyhemoglobin dissociation curve (ODC) and an increase in 2,3-diphosphoglycerate (2,3-DPG) concentration ([2,3-DPG]) in 15 patients with severe OSAHS, but some had slight daytime arterial hypoxemia while breathing room air. The aim of our study was to measure the ODC and 2,3-DPG concentrations in a group of subjects normoxemic during daytime referred to our sleep laboratory for suspicion of snoring or OSAHS. The patients were recruited during a period of 6 mo. All arterial and venous blood samples were taken early in the morning within 1 h of awakening following a full-night polysomnography. ODC and 2,3-DPG were analyzed in 88 patients: 56 OSAHS (oxygen desaturation index: 27.5 +/- 24.5) and 32 non-OSAHS. We found a significant correlation between the P50 and 2,3-DPG levels in the 88 patients: r = 0.502, P < 0.001. We observed no difference between OSAHS and non-OSAHS for the P50 and for [2,3-DPG]. There was n...Continue Reading

References

Jun 1, 1977·American Journal of Epidemiology·A H SmithG F Spears
Mar 1, 1991·The American Review of Respiratory Disease·D MaillardJ P Derenne
Jul 23, 1970·The New England Journal of Medicine·J TorranceC A Finch
Dec 1, 1968·The Journal of Clinical Investigation·C LenfantJ Faura
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·P CollardD O Rodenstein
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·V F ParreiraD O Rodenstein
Jul 13, 2004·European Journal of Applied Physiology·Gustave SavoureyJean-Marie Cottet-Emard
Aug 1, 1950·The Journal of Clinical Investigation·M MORSEM HOLDER

Citations

Jul 14, 2011·American Journal of Physiology. Endocrinology and Metabolism·Timothy EtheridgePeter W Watt
Jul 3, 2019·Journal of Cellular Physiology·Qiang MengYahan Fan

Related Concepts

Anoxemia
Blood Gas Analysis
Dioxygen
Oxyhemoglobin
Organopyrophosphates
Body Mass Index Procedure
Polysomnography
2,3-Diphosphoglycerate, (D)-Isomer
Sleep Apnea, Obstructive
Nasal Continuous Positive Airway Pressure

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