PMID: 9421109Jan 8, 1998Paper

Stability of rifampin in plasma: consequences for therapeutic monitoring and pharmacokinetic studies

Therapeutic Drug Monitoring
C Le GuellecM Breteau

Abstract

Interest in determining plasma levels of rifampin for adjustment of dosage regimens has increased, but conflicting results exist concerning rifampin stability. The authors developed a high-performance liquid chromatography assay to monitor rifampin plasma concentrations that was used to study the possible degradation of rifampin in plasma samples. This report describes the stability of rifampin in plasma kept at an ambient temperature for 24 hours or stored at -20 degrees C for 2 weeks. The possible protective effect of adding ascorbic acid was also studied. The results indicate that rifampin degrades rapidly in plasma at an ambient temperature, and a 54% loss was observed within 8 hours. This degradation can be effectively prevented by adding ascorbic acid, thus prolonging stability for up to 12 hours. The same results were observed with samples obtained as part of routine drug monitoring. Degradation was found to be greater at low rifampin concentrations. The authors subsequently demonstrated that decomposition of rifampin occurs after storage for 1 week at -20 degrees C. However, in samples supplemented with ascorbic acid before freezing, no degradation was observed within 14 days at the two concentrations tested. Rifampin w...Continue Reading

References

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Citations

Jul 22, 2009·Antimicrobial Agents and Chemotherapy·J M MiróUNKNOWN Hospital Clinic Experimental Endocarditis Study Group
Feb 7, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jean-François JourdilFrançoise Stanke-Labesque
Jul 20, 2007·Fundamental & Clinical Pharmacology·France RoblotChantal Le Guellec
Jul 3, 2007·Biomedical Chromatography : BMC·J PullenL J I Zimmermann
Jan 5, 2011·Biomedical Chromatography : BMC·Wenkui LiFrancis L S Tse
Nov 22, 2012·Journal of Clinical Pharmacy and Therapeutics·R C Milán SegoviaS Romano Moreno
Dec 18, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·E RiberaA Pahissa
Aug 26, 2014·Journal of Pharmaceutical and Biomedical Analysis·Subashini RajaramRajendran Natham
May 22, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Femke de VeldeDonald R A Uges
Sep 22, 2005·Therapeutic Drug Monitoring·Jiwen Chen, Yunsheng Hsieh
Aug 26, 1998·Therapeutic Drug Monitoring·C A Peloquin
Jan 28, 2003·Therapeutic Drug Monitoring·Nadège LimeletteChristine Fernandez
Jul 27, 2021·Drug Metabolism Reviews·Aarzoo ThakurChukwunonso K Nwabufo

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