Oct 1, 1976

Stability of salicylamide-caffeine complex at different temperatures and its thermodynamic parameters

The Journal of Pharmacy and Pharmacology
M DonbrowH B Shalom


The stability constants for formation of complexes of salicylamide with caffeine have been measured between 15 and 45degrees, by means of the solubility method. There was a linear solubility increase at all temperatures but phase diagrams indicated that at 15 and 25degrees an additional phase was formed which was found to be an insoluble 1 : 1 complex. The enthalpies and entropies of interactions were evaluated. They indicate that the interaction is exothermic and enthalpy controlled.

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Mentioned in this Paper

DRUG Screen Quant Caffeine
Drug Formulation Process
Complex (molecular entity)
Caffeine Measurement
Drug Stability

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