PMID: 2507217May 1, 1989Paper

Stability of SM-7338, a new carbapenem in mediums recommended for the susceptibility testing of anaerobic bacteria and gonococci

Diagnostic Microbiology and Infectious Disease
R N Jones, R V Gardiner

Abstract

The stability of SM-7338 was compared to that of imipenem in media used for susceptibility testing anaerobic bacteria and Neisseria gonorrhoeae. SM-7338 was more stable in all media than imipenem. For tests with anaerobic bacteria, the broth-disk elution (in thioglycolate) and other methods recommended by the National Committee for Clinical Laboratory Standards can be accurately used for SM-7338. However, the cysteine content of IsoVitaleX (25.9 g/L) supplement inactivates SM-7338 (20-fold reduction) in gonococcal susceptibility test systems with GC agar base. A cysteine-free supplement would be advised for tests with the carbapenems and clavulanic acid. The SM-7338 disk diffusion test (10 micrograms) results were not significantly influenced by the inactivating substances in the media.

References

Apr 1, 1989·Antimicrobial Agents and Chemotherapy·R N JonesM A Pfaller
Oct 1, 1988·The Journal of Antimicrobial Chemotherapy·N Woodford, C A Ison
Sep 1, 1986·Antimicrobial Agents and Chemotherapy·R Wise
Jun 7, 1985·The American Journal of Medicine·R N Jones
Mar 1, 1974·Antimicrobial Agents and Chemotherapy·T W MaierL Zubrzycki

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Citations

Jan 1, 1990·Diagnostic Microbiology and Infectious Disease·P R Murray, A C Niles
Feb 2, 2012·Internal Medicine·Yasuto SakaguchiHiroshi Miura

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