Stability of sodium valproate tablets repackaged into dose administration aids

The Journal of Pharmacy and Pharmacology
Victoria K LlewelynBeverley D Glass

Abstract

Since sodium valproate, a commonly used antiepileptic drug, has been reported to be unstable in the presence of moisture, our objective was to investigate the effect of repackaging into dose administration aids. Sodium valproate 100 mg immediate-release tablets were repackaged and stored for 56 days at accelerated conditions (40 degrees C/75% relative humidity), room temperature (25 degrees C) and under refrigeration (2-8 degrees C). Samples were analysed at 3, 7, 10, 14, 21, 35, 49 and 56 days to determine chemical stability using high-performance liquid chromatography, while physical testing included assessment of weight changes and dissolution behaviour. The results revealed that the sodium valproate content in the tablets remained within the acceptable range of 90-110% under all storage conditions for 56 days. Physical stability, however, was not maintained, with a total weight gain of 12.36% under accelerated conditions over the 56 days. Samples stored under all conditions showed variable dissolution compared to the controls, with the amount of sodium valproate in solution following 45 min of dissolution testing below 75% for half of all the intervals determined. Repackaging sodium valproate tablets into dose administratio...Continue Reading

References

Feb 1, 1990·Physiology & Behavior·L L Bellush, W N Henley
Aug 1, 1991·Chemical & Pharmaceutical Bulletin·S Gizurarson, E Bechgaard
Mar 1, 1991·The Journal of Endocrinology·A B Anwana, H O Garland
Aug 1, 1990·Pharmaceutical Research·M D DonovanG L Amidon
Aug 1, 1994·Pharmaceutical Research·L IllumS S Davis
Mar 8, 2000·International Journal of Pharmaceutics·P TengamnuayA K Mitra
Jun 6, 2000·Advanced Drug Delivery Reviews·V D RomeoC R Behl
Jun 6, 2000·Advanced Drug Delivery Reviews·V D RomeoC R Behl
Jun 6, 2000·Advanced Drug Delivery Reviews·M Hinchcliffe, L Illum
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S M van der MerweH E Junginger
Jul 21, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ana VilaMaría José Alonso
Aug 4, 2004·International Journal of Pharmaceutics·Shaoyun YuQiang Zhang
Sep 25, 2004·Journal of Pharmaceutical Sciences·Giacomo Di ColoPatrizia Chetoni
Apr 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Thomas KeanMaya Thanou
Nov 5, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bogdan I FloreaGerrit Borchard
Dec 16, 2005·AAPS PharmSciTech·Reshma D'SouzaNayanabhirama Udupa
Dec 29, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maryam AmidiWim Jiskoot
Mar 28, 2006·Journal of Pharmaceutical Sciences·Shirui MaoThomas Kissel
Aug 4, 2006·Journal of Pharmaceutical Sciences·Alexander H KraulandAndreas Bernkop-Schnürch
Oct 13, 2006·The Journal of Pharmacy and Pharmacology·G SandriC Caramella
Jun 29, 2007·International Journal of Pharmaceutics·Anchalee JintapattanakitThomas Kissel
Sep 21, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xinge ZhangChaoxing Li
Nov 21, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Oliver GermershausThomas Kissel
Jul 8, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anchalee JintapattanakitVaraporn Buraphacheep Junyaprasert
May 2, 2009·Journal of Pharmaceutical Sciences·Anchalee JintapattanakitThomas Kissel

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Citations

Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Christina KaravasiliDimitrios G Fatouros
May 29, 2012·Journal of Drug Targeting·Seung Woo ChungYoungro Byun
Jul 10, 2012·Expert Opinion on Drug Delivery·Ali Demir Sezer, Erdal Cevher
Sep 5, 2021·International Journal of Pharmaceutics·Jheel DholakiaPravin Shende

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