Stability of tactile- and pain-related fMRI brain activations: an examination of threshold-dependent and threshold-independent methods.

Human Brain Mapping
Keri S Taylor, Karen D Davis

Abstract

Functional MRI can be used to assess brain plasticity over time. To confidently attribute changes in activation patterns to cortical plasticity, it is important to establish the stability of cortical activation patterns. Because little is known concerning the stability of somatosensory-evoked brain responses, we assessed the reproducibility of within-subject responses in key somatosensory regions [thalamus, primary and secondary cortex (S1, S2)] to tactile and painful stimuli using threshold-dependent and threshold-independent analyses. Six subjects underwent four biweekly scanning sessions during which tactile and painful stimuli were applied to the hand. Standard thresholding and voxel counting techniques were compared with a novel threshold-independent method utilizing percent signal change within the regions of interest. Contralateral S1 and S2 were qualitatively reproducible during tactile stimulation, with overlapping activations >85% of the time. S2 was also highly reproducible during painful stimulation (88%), whereas S1 was less reproducible (44%). However, activation in the thalamus to both tactile and painful stimulation was highly variable. Ipsilateral activation was consistent within S2 but sparse within S1 and tha...Continue Reading

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Citations

Sep 10, 2009·Brain : a Journal of Neurology·Keri S TaylorKaren D Davis
Mar 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kazuhiro HayashiTakahiro Ushida
Mar 13, 2016·Pediatric Neurology·Susan H BrownLynda J-S Yang
Jun 15, 2015·Journal of Neuroscience Methods·Jaymin UpadhyayLino Becerra
Aug 28, 2014·NeuroImage. Clinical·Raimi L QuitonJoel D Greenspan
May 21, 2016·Frontiers in Human Neuroscience·Georgios MichailEnrico Schulz
May 21, 2016·Journal of Neurosurgery. Spine·Alex J KoefmanChristopher R P Lind

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