Stability of tandem repeats in the Drosophila melanogaster Hsr-omega nuclear RNA.

Genetics
N C HoganM L Pardue

Abstract

The Drosophila melanogaster Hsr-omega locus produces a nuclear RNA containing > 5 kb of tandem repeat sequences. These repeats are unique to Hsr-omega and show concerted evolution similar to that seen with classical satellite DNAs. In D. melanogaster the monomer is approximately 280 bp. Sequences of 19 1/2 monomers differ by 8 +/- 5% (mean +/- SD), when all pairwise comparisons are considered. Differences are single nucleotide substitutions and 1-3 nucleotide deletions/insertions. Changes appear to be randomly distributed over the repeat unit. Outer repeats do not show the decrease in monomer homogeneity that might be expected if homogeneity is maintained by recombination. However, just outside the last complete repeat at each end, there are a few fragments of sequence similar to the monomer. The sequences in these flanking regions are not those predicted for sequences decaying in the absence of recombination. Instead, the fragmentation of the sequence homology suggests that flanking regions have undergone more severe disruptions, possibly during an insertion or amplification event. Hsr-omega alleles differing in the number of repeats are detected and appear to be stable over a few thousand generations; however, both increases ...Continue Reading

Citations

Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S W McKechnieA A Hoffmann
May 18, 2007·Annual Review of Cell and Developmental Biology·Mary-Lou Pardue
Aug 10, 2019·Nucleic Acids Research·William P SchreinerAmy E Pasquinelli
Dec 23, 1999·Current Opinion in Genetics & Development·S R Eddy
Aug 8, 2002·The Journal of Investigative Dermatology·Mojgan Hell-PourmojibFranz Trautinger

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