Stability of total plasma homocysteine in perinatology

Clinica Chimica Acta; International Journal of Clinical Chemistry
Yves ThéorêtWagner V Yotov

Abstract

Typical assay methods for total homocysteine in human plasma involve EDTA-containing whole blood. Unfortunately, rapid increases of the plasma homocysteine concentrations due to cellular export are observed when the EDTA-containing samples are not stored on ice and processed shortly after collection. This is a cumbersome procedure in perinatal settings, whereby delivery usually takes place at unpredictable times. The stability of homocysteine was assessed from six placental and neonatal blood samples collected in citrate buffer. Samples were stored at 4 degrees C and tested at regular intervals for the first 24 h. There was no statistical difference in homocysteine concentrations as observed over the study storage period (mean coefficient of variation [CV] 4.9%). Citrated samples can be left in a refrigerator for at least 24 h with no effect on the plasma homocysteine concentrations.

References

May 2, 1992·Lancet·R P Steegers-TheunissenT K Eskes
Apr 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·J B UbbinkP J Becker
Jan 1, 1995·Journal of Clinical Laboratory Analysis·S J KittnerJ R Hebel
Aug 1, 1997·Obstetrics and Gynecology·A RajkovicM R Malinow

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