Stability studies and structural characterization of pramipexole

Journal of Pharmaceutical and Biomedical Analysis
Marta ŁaszczMagdalena Glice

Abstract

Stability studies of pramipexole dihydrochloride performed under following conditions of temperature and relative humidity (RH): 25 degrees C 60% RH and 40 degrees C 75% RH revealed its tendency to the water sorption and the monohydrate formation. The structural changes occurring during storage were studied by infrared spectroscopy and X-ray powder diffraction methods. The thermogravimetry technique was used to control the water sorption by the substance. Pramipexole dihydrochloride monohydrate was characterized by nuclear magnetic resonance and X-ray single crystal diffraction methods. The monohydrate crystallizes in the orthorhombic crystal system in the space group P212121.

References

Jan 1, 1997·Journal of Neural Transmission·J MajK Kołodziejczyk
Feb 26, 1999·Journal of Digital Imaging·B Williamson
Jan 15, 2008·Journal of Pharmaceutical and Biomedical Analysis·Takashi KojimaYoshiko Tsuda

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Citations

Jan 24, 2021·International Journal of Pharmaceutics·Hazal Ezgi GültekinFüsun Acartürk

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