Stabilization and regression of coronary plaques treated with pitavastatin proven by angioscopy and intravascular ultrasound--the TOGETHAR trial

Circulation Journal : Official Journal of the Japanese Circulation Society
Kazuhisa KodamaAtsushi Hirayama

Abstract

Few studies have serially monitored the change of coronary plaque after statin therapy using multiple plaque imaging modalities. A prospective open-label trial was performed to assess coronary plaque regression and stabilization following 52 weeks of pitavastatin treatment (2 mg/day). Coronary segments that included the most diseased plaque of 90 patients determined on angioscopy were analyzed using intravascular ultrasound (IVUS). The yellow grade of each plaque of 46 patients who had matched angioscopy and IVUS data was evaluated on angioscopy. Low-density lipoprotein-cholesterol (LDL-C) was reduced 34.5% (145.0+/-24.0 mg/dl to 93.6+/-22.6 mg/dl, P<0.001), and high-density lipoprotein cholesterol increased 17.8% (44.9+/-11.1 mg/dl to 51.9+/-11.7 mg/dl, P<0.001). Yellow grade decreased (2.9+/-0.8 to 2.6+/-0.7, P=0.040) during 52 weeks. The reduction of yellow grade was not correlated with the LDL-C level at 52 weeks or its change. The change of yellow grade was inversely correlated with maximum yellow grade at baseline. Percent atheroma volume on IVUS did not change during 52 weeks, but its change for 52 weeks was significantly correlated with LDL-C level at 52 weeks (Spearman's rank correlation coefficient 0.312, P=0.035). Fi...Continue Reading

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Citations

Jun 1, 2011·Drug Design, Development and Therapy·Yasuyuki KawaiKouji Kajinami
Nov 13, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Undurti N Das
Dec 29, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuki MasumuraKazuhisa Kodama
Apr 20, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Atsushi HirayamaKazuhisa Kodama
May 3, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Sei KomatsuKazuhisa Kodama
Jul 23, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshikazu KashiyamaKazuhisa Kodama
Nov 23, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Masaharu Ishihara
Feb 22, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Katsuki OkadaKazuhisa Kodama
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Mar 23, 2021·Journal of Atherosclerosis and Thrombosis·Naotaka AkutsuYasuo Okumura
Feb 19, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masakazu YamagishiUNKNOWN Japanese Circulation Society Working Group

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