PMID: 3760361Oct 1, 1986Paper

Stabilization of a derangement in adenosine triphosphate metabolism during sustained, partial ischemia in the dog heart

Journal of the American College of Cardiology
W A Neill, J S Ingwall

Abstract

Severe myocardial ischemia in dogs (perfusion 10% of normal) caused progressive deterioration in adenosine triphosphate (ATP) metabolism. Between 1/2 hour and 5 hours, myocardial ATP content fell from 55 to 6% of normal, and the sum of adenine nucleotides fell from 66 to 14% of normal. Moderate ischemia (perfusion 20 to 70%) also disturbed ATP metabolism, but to a lesser degree. Moreover, there was no significant change in the concentration of any ATP metabolite between 1/2 hour and 5 hours of moderate ischemia. ATP content was 66 and 52% of normal, and adenine nucleotide content was 73 and 59% of normal at 1/2 hour and 5 hours, respectively. Trivial ischemia (perfusion 80% or greater) barely perturbed ATP metabolism at either 1/2 hour or 5 hours. Thus, in contrast to severe or trivial ischemia, prolonged moderate ischemia produced a derangement in ATP metabolism that persisted and was relatively stable for 5 hours.

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Citations

Mar 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P HetheringtonG M Pohost
Jun 1, 1992·Cardiovascular Drugs and Therapy·J F Tubau, S H Rahimtoola
Apr 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·R Lennard, H Huddart
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G WeissG Gerstenblith
Jul 15, 1995·Circulation·A E AraiJ D Bristow
Dec 1, 1991·Circulation·J D BristowG A Pantely
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Gerd HeuschShahbudin H Rahimtoola
Jan 1, 1992·International Journal of Health Services : Planning, Administration, Evaluation·M O'Neill
Nov 27, 2014·Frontiers in Psychology·Joanna Rączaszek-LeonardiAdam Sochanowicz
Oct 28, 1998·Physiological Reviews·G Heusch

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