PMID: 708743Sep 27, 1978Paper

Stabilization of adenovirus nuclear RNA by intercalating drugs

Biochimica Et Biophysica Acta
H P Madore, L J Bello

Abstract

The effect of the intercalating drugs proflavine, ethidium bromide and daunomycin on the rate of degradation of newly synthesized adenovirus RNA was examined. As shown previously for heterogeneous nuclear RNA (HnRNA) and 45 S precursor ribosomal RNA (pre-rRNA), proflavine immediately stabilizes newly synthesized adenovirus RNA, while ethidium bromide stabilizes the RNA after a 30--60 min lag period. In contrast to its effect on HnRNA and pre-rRNA, daunomycin also stabilizes newly synthesized adenovirus RNA. These results are consistent with the hypothesis that the processing of late adenovirus nuclear RNA involves cleavage of base-paired regions by specific cellular nucleases.

References

Mar 1, 1977·Nucleic Acids Research·A YannarellT E Webb
Jan 1, 1975·Cold Spring Harbor Symposia on Quantitative Biology·L PhilipsonT Persson
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P M McGuireL D Hodge
Sep 28, 1973·Science·J E DarnellG R Molloy
Mar 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J T ParsonsM Green
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·L PhilipsonJ E Darnell

Related Concepts

Acridines
Adenoviruses, Human
Cerubidine
Drug Stability
Novidium
Proflavine
RNA, Viral

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