Stabilization of all-trans retinol by loading lipophilic antioxidants in solid lipid nanoparticles

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Jun-Pil JeeChong-Kook Kim

Abstract

Loading of drugs into the solid matrix of solid lipid nanoparticles (SLNs) can be one of effective means to protect them against chemical degradation. In this study, the SLNs for all-trans retinol (AR) were formulated to improve the stability of AR, whose chemical instability has been a limiting factor in its clinical use. First of all, the physicochemical properties of AR-loaded SLNs, including mean particle diameter and zeta potential, were modulated by changing the total amount of surfactant mixture and the mixing ratio of eggPC and Tween 80 as surfactant mixture. The AR-loaded SLNs formulation was irradiated with a 60-W bulb to investigate the photostability. The extent of photodegradation was measured by high-performance liquid chromatography. The mean particle diameter and zeta potential of the smallest SLNs were 96 nm and -28 mV, respectively. The loading of AR in optimized SLNs formulations rather decelerated the degradation of AR, compared with AR solution dissolved in methanol. Our subsequent study showed that the co-loading of antioxidants greatly enhanced the stability of AR loaded in SLNs, compared with those loaded in SLNs without antioxidant. The photostability at 12 h of AR in SLNs was enhanced folds (43% approx...Continue Reading

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Citations

Apr 10, 2013·Journal of Biomaterials Science. Polymer Edition·Shih-Jer HuangLi-Fang Wang
Sep 12, 2008·Drug Development and Industrial Pharmacy·Santo Scalia, Matteo Mezzena
Feb 9, 2010·Drug Development and Industrial Pharmacy·Chang-Moon LeeKi-Young Lee
May 24, 2011·Expert Opinion on Drug Delivery·Mirjana Gašperlin, Mirjam Gosenca
Mar 8, 2012·Expert Opinion on Drug Delivery·Carmelo Puglia, Francesco Bonina
Nov 11, 2008·International Journal of Pharmaceutics·Jana PardeikeRainer H Müller
May 3, 2008·International Journal of Cosmetic Science·E B Souto, R H Müller
Jan 21, 2012·Journal of Food Science·Mandar R Patel, M Fernanda San Martin-Gonzalez
Feb 28, 2015·International Journal of Cosmetic Science·X-h LiuW-P Zhang
Mar 27, 2013·Pharmaceutical Development and Technology·Rawia M KhalilMona Basha
Jan 1, 2010·Annual Review of Food Science and Technology·David Julian McClements
Nov 26, 2010·International Journal of Pharmaceutics·Sunatda ArayachukeatThapakorn Tree-Udom
Sep 29, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Márcio Carocho, Isabel C F R Ferreira
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Mar 31, 2021·International Journal of Biological Macromolecules·Neda Karimi KhorramiDavid Julian McClements

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