PMID: 9177807Jan 1, 1997Paper

Stabilization of an inserted tricalcium phosphate spacer enhances the healing of a segmental tibial defect in sheep

Archives of Orthopaedic and Trauma Surgery
T J GaoT S Lindholm

Abstract

The effect of inserting a tricalcium phosphate (TCP) spacer stabilized by a rigid or non-rigid fixation technique on the healing of segmental tibial defects of critical size was established. The osteotomized tibiae, 11 with and 8 without TCP spacers, were fixed by an external circular device in 11 mature sheep and by plates in 8 mature sheep, respectively. Healing was evaluated roentgenographically 16 weeks after the operation. Compared with the defects without TCP spacers, enhanced stability and healing were observed in the defects with TCP spacers under an identical external fixation. Furthermore, a significantly higher incidence of healing was obtained with plate fixation than with external device fixation in the TCP-implanted defects (P < 0.04). An abundant bridging callus was roentgenograpically demonstrated in most of the healed defects, but none in the unhealed defects. The TCP spacer with its mechanical integrity enhances the stability of external fixation, and the stable immobilization provided by rigid fixation is essential for osteoconduction of an inserted TCP spacer in the healing of segmental diaphyseal defects in sheep.

References

May 1, 1979·Plastic and Reconstructive Surgery·J W Ferraro
Jan 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E J ChealS M Perren
Jan 1, 1990·Archives of Orthopaedic and Trauma Surgery·U HeitemeyerM Körber
Jun 1, 1989·Acta Orthopaedica Scandinavica·H OhgushiA I Caplan
Aug 1, 1986·Journal of Biomechanical Engineering·A M DiGioiaW C Hayes
Aug 1, 1985·The Journal of Bone and Joint Surgery. British Volume·A E Goodship, J Kenwright
Jan 1, 1982·Journal of Biomechanics·N P ReddyJ B Brunski
Sep 1, 1981·The Journal of Trauma·D SeligsonM H Pope

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Citations

Feb 4, 2009·International Orthopaedics·E M NelissenR G H H Nelissen
Jul 6, 2014·International Orthopaedics·Jean-Charles Aurégan, Thierry Bégué
Nov 6, 1998·Nature·A R Means
May 19, 2020·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Catherine C ClassenBrendan Beckett
Jun 28, 2001·Journal of Biomedical Materials Research·Z CongZ Xingdong
Nov 2, 2019·Biochemical Society Transactions·Ying-Chi ChaoManuela Zaccolo

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