Stabilization of anionic adducts in negative ion electrospray mass spectrometry

Analytical Chemistry
Yang Cai, R B Cole

Abstract

Attachment of small anions to neutral molecules is an important ionization mechanism in negative ion electrospray mass spectrometry. In this report, the tendency for different anions to remain attached to selected analyte compound classes has been systematically investigated. A rationale for the formation and stability of preferred anionic adducts is proposed in light of thermodynamic considerations. A series of collision-induced dissociation experiments reveals that the gas-phase basicities of the deprotonated analyte molecule ([M - H]-) and the anion moiety play important roles in determining the stability of anionic adducts. Adducts of the form [M - H]-...H+...[anion]- manifest increased stability when the two anions have similar gas-phase basicities. Within certain limitations, the difference in deltaG degrees values for proton combination with [M - H]- and with [anion]- can be used as a first-order predictor of adduct stability. In addition, stability increases with the rising gas-phase basicities of the two moieties. The specific interaction between a small inorganic anion (bisulfate) and a neutral analyte molecule (alpha-D-glucose) in the form of multiple hydrogen bonding has also been affirmed by computer modeling to co...Continue Reading

References

Jul 1, 1993·Journal of the American Society for Mass Spectrometry·R F Straub, R D Voyksner
Apr 1, 1993·Journal of the American Society for Mass Spectrometry·F M WamplerP Kebarle

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Citations

Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Tawnya G FlickEvan R Williams
Oct 15, 2011·Journal of the American Society for Mass Spectrometry·Xiaohua Liu, Richard B Cole
May 4, 2004·Journal of the American Society for Mass Spectrometry·Ana K Vrkic, Richard A J O'Hair
Jan 18, 2005·Journal of the American Society for Mass Spectrometry·Yanjie Jiang, Richard B Cole
Mar 26, 2009·Journal of the American Society for Mass Spectrometry·Loubna A HammadYehia Mechref
May 18, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Songmei GaoH T Karnes
Mar 27, 2003·Bioorganic & Medicinal Chemistry Letters·Tonika Chatterji, Kent S Gates
Dec 18, 2002·Journal of the American Society for Mass Spectrometry·Yang CaiRichard B Cole
Dec 18, 2013·Journal of the American Society for Mass Spectrometry·Michael C ThomasGeoffrey W Nette
May 8, 2007·Analytica Chimica Acta·Eduard RogatskyDaniel T Stein
Feb 22, 2011·Rapid Communications in Mass Spectrometry : RCM·Marina V KosevichOleg A Boryak
Jun 24, 2006·Biosensors & Bioelectronics·G CiccarellaG P Suranna
Aug 31, 2013·Carbohydrate Polymers·Nelson R VinuezaHilkka I Kenttämaa
Feb 9, 2018·Journal of the American Society for Mass Spectrometry·Ignacy RzagalinskiDietrich A Volmer
Jul 19, 2002·Journal of Mass Spectrometry : JMS
Feb 16, 2006·Rapid Communications in Mass Spectrometry : RCM·V V S LakshmiM Vairamani
Apr 6, 2007·Analytical and Bioanalytical Chemistry·Clemens WaltherThorald Bergmann
Jan 22, 2021·Journal of the American Society for Mass Spectrometry·J Michael SuttonMichael G Bartlett
Aug 1, 2005·Journal of the American Society for Mass Spectrometry·Konstantinos KavallieratosJohanna M Rodriguez
Mar 21, 2017·Journal of the American Society for Mass Spectrometry·Elahe Honarvar, Andre R Venter
Aug 2, 2017·Journal of the American Society for Mass Spectrometry·Maria A A RodriguesJosé P Da Silva

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