Stabilization of chitosan based electrospun nanofibers through a simple and safe method

Materials Science & Engineering. C, Materials for Biological Applications
Milad FadaieNegar Azarpira

Abstract

A simple and safe method was used to stabilize nanofibrous structure of chitosan (CS) based mats obtained from acidic solution. The electrospun CS based nanofibrous mats were fabricated using CS/poly ethylene oxide in acetic acid aqueous solution. Exposure to water vapor at 40-70 °C for 30-120 min was implemented in order to stabilizing the CS mats. Scanning electron microscopy of the treated mats revealed preservation of nanofibrous structure after immersion in phosphate buffered saline (pH = 7.4). This result along with infrared spectroscopy and thermogravimetric analysis confirmed removal of acetic acid residues and neutralization of CS mats after treatment with water vapor. Stabilization with water vapor also led to augmentation in tensile strength and elastic moduli of CS mats comparing to as-spun mats while the elongation was decreased. Furthermore, the crystallinity and thermal stability of mats were slightly increased after neutralization. In comparison with glutaraldehyde cross-linked mats, water vapor treated mats showed higher swelling ratio and enhanced cell compatibility.

Citations

Dec 5, 2019·Tissue Engineering. Part B, Reviews·Elnaz Sadat MirdamadiMehran Solati-Hashjin
Apr 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Bingyan Li, Xuhong Yang
May 1, 2021·Pharmaceutics·Andreea Teodora IacobLenuta Profire
Nov 18, 2021·Advanced Healthcare Materials·Liszt Y C Madruga, Matt J Kipper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biomacromolecules
Jessica D Schiffman, Caroline L Schauer
International Journal of Biological Macromolecules
Zhi-Hong ZhangYu-Jia Liu
International Journal of Biological Macromolecules
K Jalaja, Nirmala R James
© 2022 Meta ULC. All rights reserved