Stabilization of curcumin by complexation with divalent cations in glycerol/water system.

Bioinorganic Chemistry and Applications
Bachar ZebibVirginie Noirot

Abstract

The purpose of present study was to stabilize curcumin food pigment by its complexation with divalent ions like (Zn(2+), Cu(2+), Mg(2+), Se(2+)), in "green media" and evaluate its stability in vitro compared to curcumin alone. The curcumin complexes were prepared by mechanical mixture of curcumin and sulfate salts of each metal (metal : curcumin 1/1mol) into unconventional and nontoxic glycerol/water solvent. Two stoichiometry of complex were obtained, 1 : 1 and 1 : 2 (metal/curcumin), respectively. On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone.

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Citations

May 9, 2013·Drug Discovery Today·Vivian SoetiknoKenichi Watanabe
Feb 26, 2016·Journal of Agricultural and Food Chemistry·Jiahn-Haur LiaoTzu-Hua Wu
Oct 15, 2013·Biophysical Chemistry·Angela L Picciano, Timothy D Vaden
Nov 12, 2016·Nutrients·Aline Renata PavanJean Leandro Dos Santos
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Jun 7, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Purusotam Basnet, Natasa Skalko-Basnet
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Oct 24, 2017·Nanoscale·Devleena SamantaRichard N Zare
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Oct 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingyi GuoGuangshan Zhu
Apr 4, 2021·International Journal of Molecular Sciences·Camelia-Elena Iurciuc TincuLăcrămioara Ochiuz
Jul 13, 2021·ACS Chemical Neuroscience·Lalita Subedi, Bhakta Prasad Gaire

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