PMID: 8957707Jan 1, 1996Paper

Stabilization of nerve growth factor in controlled release polymers and in tissue

Journal of Biomaterials Science. Polymer Edition
C E KrewsonW M Saltzman

Abstract

We have studied the release of nerve growth factor (NGF), a protein under consideration for treatment of Alzheimer's Disease, from polymer matrices and microspheres to characterize the stability of NGF, the dynamics of NGF release, and the distribution of NGF within the brain interstitium. Poly(ethylene-co-vinyl acetate) (EVAc) disks and poly(L-lactic acid) (PLA) microspheres were formed by codispersing NGF with one of a variety of molecules. The mass of mouse NGF (mNGF) detected following release from EVAc disks into buffered saline varied five-fold over the range of codispersants studied, with carboxymethyldextran providing optimal release, while the mass of recombinant human NGF (rhNGF) released varied four-fold from both EVAc disks and PLA microspheres, with albumin and carboxymethyldextran providing optimal release. Variation of the codispersant species significantly affected NGF release into buffered saline; it also had a noticeable, but small, effect of the amount of NGF found in the brain tissue following implantation of a polymer device. To improve NGF retention in tissue, NGF was conjugated to 70,000 molecular weight dextran and incorporated into a polymeric device. The distribution of NGF was enhanced by conjugation;...Continue Reading

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Citations

Sep 19, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·M F Haller, W M Saltzman
Nov 5, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·J M PéanJ P Benoit
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J P BenoitP Menei
Aug 16, 2000·Advanced Drug Delivery Reviews·M S Shoichet, S R Winn
Jun 6, 2000·Advanced Drug Delivery Reviews· Mark Saltzman W, S P Baldwin
Sep 16, 1998·Current Opinion in Chemical Biology·S D Putney
Feb 24, 2001·Journal of Microencapsulation·Y OzalpV Hasirci
Jul 26, 2015·International Journal of Pharmaceutics·Amin SwedFrank Boury
Mar 30, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Célia FaustinoCatarina Pinto Reis
Mar 15, 2006·International Journal of Pharmaceutics·N Popovic, P Brundin
Mar 29, 2000·Journal of Biomedical Materials Research·L LuA G Mikos
Apr 12, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Brenda FroesAngela Kinoshita
Jul 18, 2002·Nature Reviews. Drug Discovery·W Mark Saltzman, William L Olbricht
Mar 6, 1998·Nature Biotechnology·S D Putney, P A Burke
Dec 13, 2006·The European Journal of Neuroscience·Xiaohua YanElizabeth A Debski
Apr 23, 2008·Pediatric Research·Serge Kobsa, W Mark Saltzman
Jan 5, 2002·Journal of Biomedical Materials Research·Caroline N DemersL'Hocine Yahia
Jul 27, 2012·Environmental Science & Technology·Asha N SharmaM Todd Walter
Nov 3, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuanfei WangMolly S Shoichet

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