Stabilization of thalamo-cortical long-term potentiation by the amygdala: cholinergic and transcription-dependent mechanisms

The European Journal of Neuroscience
Hans C DringenbergSummer Tomaszek

Abstract

Synaptic potentiation allows neurons to enhance excitability and store information for extended time periods. We examined the role of the amygdaloid complex, known to facilitate long-term memory encoding, to influence synaptic strength at thalamo-cortical synapses. In urethane-anaesthetized rats, theta-burst stimulation of the dorsal lateral geniculate nucleus of the thalamus induced early phase (1-2 h) long-term potentiation (LTP) of the field postsynaptic potential (fPSP) recorded in the ipsilateral primary visual cortex. Electrical stimulation (100 Hz) of the amygdala 5 min after thalamic stimulation converted early phase LTP to stable late-phase (> 4 h) LTP. This effect was not correlated with the degree of electrocorticographic activation of V1 induced by amygdala stimulation. Amygdala stimulation without thalamic theta-burst stimulation did not change thalamo-cortical fPSPs. The centrally acting cholinergic-muscarinic receptor antagonist scopolamine (1 mg/kg, i.p.), but not peripherally acting methyl-scopolamine, completely blocked the amygdala-induced conversion of early to late-phase thalamo-cortical LTP. Further, ventricular application of the transcription inhibitor anisomycin (250 micro g) reduced amygdala-induced la...Continue Reading

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Citations

May 12, 2009·Nature Neuroscience·Andrei T PopescuDenis Paré
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sam F Cooke, Mark F Bear
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sungkun ChunStanislav S Zakharenko
Dec 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andrei T PopescuDenis Paré
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·James L McGaugh
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Dec 26, 2012·Neurobiology of Learning and Memory·Candice M ChavezNorman M Weinberger
Sep 8, 2006·Neuroreport·Elisabeth Wallhäusser-FrankeClaudia Mahlke
Dec 31, 2005·Journal of Neurophysiology·Akio Hirata, Manuel A Castro-Alamancos

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