PMID: 6707881Feb 1, 1984

Stabilized normal-phase high-performance liquid chromatographic analysis of aspirin and salicylic acid in solid pharmaceutical dosage forms

Journal of Pharmaceutical Sciences
R N GalanteW M Grim

Abstract

A simultaneous analysis of aspirin and nonaspirin salicylates in solid pharmaceutical dosage forms is described. Two separate extraction procedures are employed, one for plain aspirin tablets and one for tablets containing aspirin plus buffers or antacids. The analyses of the extracted samples are accomplished by a stabilized normal-phase high-performance liquid chromatographic (HPLC) procedure. Prepared samples and standards are stable for up to 24 h, and the methodology is suitable for an automated HPLC system.

Related Concepts

Antacids
Zorprin
Ampholytes
High Pressure Liquid Chromatography Procedure
Drug Stability
Salicylic Acids
Salicylic Acid

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