Stable and pH-sensitive nanogels prepared by self-assembly of chitosan and ovalbumin

Langmuir : the ACS Journal of Surfaces and Colloids
Shaoyong YuMing Jiang

Abstract

Two natural macromolecules, chitosan and ovalbumin, were used to produce nanogels by a new, green, and convenient method. Chitosan and ovalbumin solutions were mixed; the pH of the resulting solution was adjusted; and the solution was successively stirred and heated. After that, ovalbumin gelled forming nanospheres. The chitosan chains are supposed to be partly trapped in the nanogel core upon heating because of the electrostatic attractions between chitosan and ovalbumin, while the rest of the chitosan chains should form the shell of the nanogels. The nanogels did not change the size distribution after long-time storage and did not dissociate in the pH range of 2-10.5. The dispersibility, size, and hydrophobicity/hydrophilicity of the nanogels are pH-dependent. The nanogels are good candidates for cosmetic and pharmaceutical applications.

References

Aug 11, 1998·Nature·P F KiserD Needham
Mar 17, 2001·Advanced Drug Delivery Reviews·K A JanesM J Alonso
Aug 23, 2001·Advanced Drug Delivery Reviews·L IllumS S Davis
Nov 24, 2001·Advanced Drug Delivery Reviews·M ThanouH E Junginger
Apr 25, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Radi Hejazi, Mansoor Amiji
Nov 11, 2003·Biomacromolecules·Entsar I RabeaWalter Steurbaut
Oct 20, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunil A AgnihotriTejraj M Aminabhavi
Jun 9, 2005·Journal of the American Chemical Society·Tatiana K BronichAlexander V Kabanov
Sep 13, 2005·Biomacromolecules·Magdolna BodnarJanos Borbely

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Citations

Mar 7, 2012·Applied Microbiology and Biotechnology·Jianzhi WangPingping Hou
Jun 2, 2009·Critical Reviews in Food Science and Nutrition·David Julian McClementsJochen Weiss
Aug 5, 2014·Therapeutic Delivery·Lærke ArnfastStefania Baldursdottir
Jun 28, 2014·International Journal of Biological Macromolecules·Bin ZhouBin Li
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Paulo A G SoaresMaria G Carneiro-da-Cunha
Feb 16, 2016·Carbohydrate Polymers·Jatesuda JirawutthiwongchaiSuwabun Chirachanchai
Jun 27, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Martha K Pastuszka, J Andrew MacKay
Jun 12, 2012·Journal of Colloid and Interface Science·Baoru YinPing Yao
Apr 13, 2010·International Journal of Pharmaceutics·Jianing QiChong Huang
Oct 9, 2008·Advanced Drug Delivery Reviews·Mehrdad HamidiPedram Rafiei
May 22, 2007·Journal of Colloid and Interface Science·Weijun LiuYing Hu
Jun 30, 2009·Angewandte Chemie·Alexander V Kabanov, Serguei V Vinogradov
Oct 25, 2011·Journal of Biomedical Materials Research. Part a·Mengjie ChenXin Chen
Mar 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bei JinRiji Qiu
Nov 9, 2010·Advances in Colloid and Interface Science·Christophe Schmitt, Sylvie L Turgeon
Apr 5, 2016·International Journal of Biological Macromolecules·Guilherme A MagalhãesRegina C M de Paula
Oct 24, 2012·International Journal of Pharmaceutics·Kunkun ZhuBin Li
Aug 12, 2014·Biotechnology Advances·Yu YangMeiwan Chen
Dec 27, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nai-Pu HeFei Pei
Oct 29, 2013·Colloids and Surfaces. B, Biointerfaces·Sougata JanaSanat Kumar Basu
May 24, 2011·Journal of Colloid and Interface Science·István SzilágyiMichal Borkovec
Jan 21, 2015·Colloids and Surfaces. B, Biointerfaces·Liufeng LinYijie Chen
Jun 6, 2016·Colloids and Surfaces. B, Biointerfaces·Yuntao WangYijie Chen
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wing-Fu Lai, Zhen-Dan He
Aug 22, 2020·Expert Opinion on Drug Delivery·Islam A Hassanin, Ahmed O Elzoghby
Dec 1, 2015·Journal of Food and Drug Analysis·M Abd ElgadirMd Zaidul Islam Sarker

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