Stable Encoding of Visual Cues in the Mouse Retrosplenial Cortex.

Cerebral Cortex
Anna PowellAdam Ranson

Abstract

The rodent retrosplenial cortex (RSC) functions as an integrative hub for sensory and motor signals, serving roles in both navigation and memory. While RSC is reciprocally connected with the sensory cortex, the form in which sensory information is represented in the RSC and how it interacts with motor feedback is unclear and likely to be critical to computations involved in navigation such as path integration. Here, we used 2-photon cellular imaging of neural activity of putative excitatory (CaMKII expressing) and inhibitory (parvalbumin expressing) neurons to measure visual and locomotion evoked activity in RSC and compare it to primary visual cortex (V1). We observed stimulus position and orientation tuning, and a retinotopic organization. Locomotion modulation of activity of single neurons, both in darkness and light, was more pronounced in RSC than V1, and while locomotion modulation was strongest in RSC parvalbumin-positive neurons, visual-locomotion integration was found to be more supralinear in CaMKII neurons. Longitudinal measurements showed that response properties were stably maintained over many weeks. These data provide evidence for stable representations of visual cues in RSC that are spatially selective. These ma...Continue Reading

References

Apr 20, 1999·Neuroreport·B G Cooper, S J Mizumori
Apr 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas Wolbers, Christian Büchel
May 16, 2007·Psychological Review·Patrick ByrneNeil Burgess
Nov 9, 2007·The Journal of Comparative Neurology·Hideshi Shibata, Jumpei Naito
Nov 27, 2008·The European Journal of Neuroscience·Helen H J PothuizenSeralynne D Vann
Jan 23, 2009·Nature Methods·Marco MankOliver Griesbeck
Oct 9, 2009·Nature Reviews. Neuroscience·Seralynne D VannEleanor A Maguire
Mar 2, 2010·Neuron·Cristopher M Niell, Michael P Stryker
May 5, 2012·Journal of Computational Neuroscience·Florian RaudiesMichael E Hasselmo
Aug 23, 2012·PloS One·Stephen D AugerEleanor A Maguire
Oct 23, 2012·Nature Neuroscience·David J MargolisFritjof Helmchen
Nov 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Emily A MankinJill K Leutgeb
Feb 12, 2013·Nature Neuroscience·Yaniv ZivMark J Schnitzer
May 15, 2013·Current Biology : CB·Aslı AyazMatteo Carandini
Jul 23, 2013·Nature Neuroscience·Pierre-Olivier PolackPeyman Golshani
Nov 5, 2013·Nature Neuroscience·Aman B SaleemMatteo Carandini
Mar 19, 2014·Cell·Yu FuMichael P Stryker
Jul 16, 2014·Behavioural Brain Research·Coralie Elduayen, Etienne Save
Jun 25, 2015·Frontiers in Molecular Neuroscience·Tomonari MurakamiKenichi Ohki
Jul 7, 2015·Nature Neuroscience·Andrew S Alexander, Douglas A Nitz
Jul 15, 2015·Nature Neuroscience·Hiroshi Makino, Takaki Komiyama
Aug 19, 2015·ELife·Stephen D AugerEleanor A Maguire
Sep 9, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Naoki YamawakiGordon M G Shepherd
Jan 7, 2017·ELife·Jun ZhuangJack Waters
Jan 18, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Claudia ClopathTobias Rose
Jan 9, 2018·Journal of Cognitive Neuroscience·Stephen D Auger, Eleanor A Maguire
Mar 22, 2018·Cell Reports·Daisuke ShimaokaMatteo Carandini
Sep 18, 2018·Brain and Neuroscience Advances·Anna S MitchellAndrew J D Nelson
Oct 18, 2018·Scientific Reports·Brian B JeonSandra J Kuhlman

❮ Previous
Next ❯

Citations

Jan 3, 2021·Cerebral Cortex·Adam M P MillerDavid M Smith
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Christopher M DillinghamSeralynne D Vann
Nov 8, 2020·Cerebral Cortex·Sara R J GilissenLutgarde Arckens
Dec 10, 2020·Brain and Neuroscience Advances·Andrew S AlexanderMichael E Hasselmo
Dec 29, 2020·Current Opinion in Neurobiology·Tom Flossmann, Nathalie L Rochefort
Sep 24, 2021·Neurobiology of Learning and Memory·Eleonora LomiKate J Jeffery

❮ Previous
Next ❯

Software Mentioned

Matlab
lsqcurvefit
vartestn
fitnlm
Suite2P

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.