Stable formation of compositionally unique stress granules in virus-infected cells.

Journal of Virology
Joanna PiotrowskaKurt E Gustin

Abstract

Stress granules are sites of mRNA storage formed in response to a variety of stresses, including viral infections. Here, the mechanisms and consequences of stress granule formation during poliovirus infection were examined. The results indicate that stress granules containing T-cell-restricted intracellular antigen 1 (TIA-1) and mRNA are stably constituted in infected cells despite lacking intact RasGAP SH3-domain binding protein 1 (G3BP) and eukaryotic initiation factor 4G. Fluorescent in situ hybridization revealed that stress granules in infected cells do not contain significant amounts of viral positive-strand RNA. Infection does not prevent stress granule formation in response to heat shock, indicating that poliovirus does not block de novo stress granule formation. A mutant TIA-1 protein that prevents stress granule formation during oxidative stress also prevents formation in infected cells. However, stress granule formation during infection is more dependent upon ongoing transcription than is formation during oxidative stress or heat shock. Furthermore, Sam68 is recruited to stress granules in infected cells but not to stress granules formed in response to oxidative stress or heat shock. These results demonstrate that st...Continue Reading

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J K RoseD Baltimore
Oct 1, 1989·The Journal of Cell Biology·R F Duncan, J W Hershey
Aug 1, 1987·Archives of Biochemistry and Biophysics·R F Duncan, J W Hershey
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·Y Yogo, E Wimmer
Feb 1, 1993·Molecular and Cellular Biology·M E ClarkA Dasgupta
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·A E McBrideK Kirkegaard
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·L B BlynE Ehrenfeld
Aug 1, 1997·Journal of Virology·L B BlynE Ehrenfeld
Aug 8, 1998·Genes & Development·A V Gamarnik, R Andino
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·A GradiN Sonenberg
Dec 21, 2000·The Journal of Cell Biology·N KedershaP Anderson
Mar 19, 2003·The Journal of Cell Biology·Helene TourrièreJamal Tazi
Apr 12, 2003·Cell Biology International·Pavel A IvanovElena S Nadezhdina
Jul 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·E REICH TATUMEL
Dec 4, 2003·Biochimica Et Biophysica Acta·Kiven E Lukong, Stéphane Richard
Sep 17, 2004·Molecular Biology of the Cell·Natalie GilksPaul Anderson
Feb 22, 2005·The Journal of General Virology·Denise Egger, Kurt Bienz
Apr 23, 2005·The Journal of Biological Chemistry·Nickolay NeznanovAndrei V Gudkov
Jun 3, 2005·Molecular Biology of the Cell·Gerald M McInerneyPeter Liljeström
Jun 22, 2005·The Journal of Cell Biology·Nancy KedershaPaul Anderson
Jul 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Marie-Eve BordeleauJerry Pelletier
Jan 28, 2006·Journal of Virology·Jennifer A SmithLeslie A Schiff
Mar 15, 2006·Nature Chemical Biology·Marie-Eve BordeleauJerry Pelletier
May 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mohamed M Emara, Margo A Brinton
Jun 22, 2007·Journal of Virology·Rushika PereraBert L Semler
Oct 10, 2007·Methods in Enzymology·Nancy Kedersha, Paul Anderson
Nov 17, 2007·Cell Host & Microbe·James P WhiteRichard E Lloyd
Nov 30, 2007·Journal of Virology·Nogi ParkKurt E Gustin

❮ Previous
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Citations

Jul 27, 2012·Molecular Biology of the Cell·Lucas C ReinekeRichard E Lloyd
May 25, 2012·Journal of Virology·Renée L FinnenBruce W Banfield
Jul 15, 2011·Journal of Virology·Fabian Borghese, Thomas Michiels
Jun 24, 2011·Journal of Virology·James P WhiteRichard E Lloyd
Nov 26, 2010·Journal of Virology·Anthony Khong, Eric Jan
Dec 15, 2010·Journal of Virology·M Simpson-HolleyJ H Connor
Oct 19, 2012·Journal of Virology·Phat X DinhAsit K Pattnaik
Mar 29, 2013·Journal of Virology·Martijn A LangereisFrank J van Kuppeveld
Oct 1, 2011·Journal of Virology·James P White, Richard E Lloyd
Oct 25, 2012·Molecular Neurodegeneration·Anaïs AulasChristine Vande Velde
Jul 5, 2012·PLoS Pathogens·Richard E Lloyd
Nov 30, 2013·International Journal of Molecular Sciences·Flora Sánchez-Jiménez, Víctor Sánchez-Margalet
Dec 14, 2011·Viruses·Hilda Montero, Vicenta Trujillo-Alonso
Apr 2, 2014·Microbial Pathogenesis·Bhawana JainAmita Jain
Aug 26, 2014·Trends in Immunology·Koji OnomotoTakashi Fujita
Nov 3, 2014·Annual Review of Virology·Wei-Chih Tsai, Richard E Lloyd
Jun 19, 2012·Virus Research·Fernando Valiente-EcheverríaAndrew J Mouland
Mar 13, 2012·Trends in Microbiology·James P White, Richard E Lloyd
Apr 5, 2013·Wiley Interdisciplinary Reviews. RNA·Richard E Lloyd
Nov 12, 2013·International Journal of Cancer. Journal International Du Cancer·Kyoung-Jae WonMisun Won
Mar 30, 2016·The Journal of Cell Biology·Nancy KedershaPaul Anderson
Sep 4, 2015·Doklady. Biochemistry and Biophysics·A A IvanovaS V Razin
Aug 26, 2014·Virus Research·Shuo WuZhaohua Zhong
Jan 8, 2013·Virology·Lucas C Reineke, Richard E Lloyd
May 23, 2012·RNA Biology·Ken MatsumotoMasafumi Tsujimoto
Jul 20, 2010·RNA Biology·Roberta Busà, Claudio Sette
May 7, 2013·Insect Biochemistry and Molecular Biology·Li ZhuTakahiro Kusakabe
Oct 23, 2012·Cell Host & Microbe·Ian Mohr, Nahum Sonenberg
Jun 18, 2016·Viruses·Jason Liem, Jia Liu
Jul 2, 2016·Viruses·Natalia Poblete-DuránFernando Valiente-Echeverría
Sep 10, 2016·Frontiers in Microbiology·Ana L C ValadãoLuciana B de Arruda
Dec 22, 2016·Viruses·Wendy Ullmer, Bert L Semler
Jan 10, 2018·Frontiers in Plant Science·Kristiina MäkinenMaija Pollari

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