PMID: 2493377Feb 1, 1989Paper

Stable human immunodeficiency virus encephalopathy in two infants receiving early intravenous gammaglobulin plus antimicrobial prophylaxis

European Journal of Pediatrics
U A HunzikerR A Seger

Abstract

Two infants with human immunodeficiency virus (HIV) infection, encephalopathy, intrathecal anti-HIV IgG antibody production and (in one case) the presence of HIV antigen received monthly doses of intravenous gammaglobulin (IVGG) and daily antimicrobial prophylaxis starting at the ages of 6 and 9 months respectively. The follow-up over 15 and 12 months revealed a favourable course with remarkable improvement in visuo-spatial functions, receptive language, play behaviour and fine motor skills, as well as in muscle tone, pyramidal tract signs and vigilance in case 1, and near normalization in case 2. Viability of HIV in peripheral blood mononuclear cells, antigen in serum and cellular immunodeficiency, however, all remained unchanged. We suggest that neurological complications of encephalopathy in paediatric acquired immunodeficiency syndrome may have a slower progression when IVGG treatment plus antimicrobial prophylaxis is started early.

References

Jan 1, 1988·American Journal of Diseases of Children·A L BelmanA Rubinstein
Nov 16, 1985·Lancet·E JovaisasD Löwenthal
Feb 1, 1986·American Journal of Diseases of Children·A GuptaA Rubinstein
May 1, 1986·Pediatric Infectious Disease·R LampertP Thomas
May 1, 1986·Pediatric Infectious Disease·T A Calvelli, A Rubinstein
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Mar 1, 1984·Pediatrics·M J CowanA J Ammann
Jan 1, 1964·Canadian Anaesthetists' Society Journal·H C CHURCHILL-DAVIDSON, R P WISE

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Citations

Oct 1, 1992·Archives of Disease in Childhood·N WagnerM Becker
May 1, 1989·Archives of Disease in Childhood·D NadalR A Seger
Mar 15, 2002·The Journal of Peptide Research : Official Journal of the American Peptide Society·H L BallM A Baldwin
Jun 1, 1991·Developmental Medicine and Child Neurology·B SchmittG Jacobi

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