PMID: 15378838Sep 24, 2004Paper

Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals

Radiation Research
Catherine R MitchellD J Brenner

Abstract

A multicolor banding (mBAND) fluorescence in situ hybridization technique was used to investigate the presence inhuman populations of a stable biomarker-intrachromosomal chromosome aberrations-of past exposure to high-LET radiation. Peripheral blood lymphocytes were taken from healthy Russian nuclear workers occupationally exposed from 1949 onward to either plutonium, gamma rays or both. Metaphase spreads were produced and chromosomes 1 and 2 were hybridized with mBAND FISH probes and scored for intra-chromosomal aberrations. A large yield of intrachromosomal aberrations was observed in both chromosomes of the individuals exposed to high doses of plutonium, whereas there was no significant increase over the (low) background control rate in the population who were exposed to high doses of gamma rays. Interchromosome aberration yields were similar in both the high plutonium and the high gamma-ray groups. These results for chromosome 1 and 2 confirm and extend data published previously for chromosome 5. Intrachromosomal aberrations thus represent a potential biomarker for past exposure to high-LET radiations such as alpha particles and neutrons and could possibly be used as a biodosimeter to estimate both the dose and type of radi...Continue Reading

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Citations

Dec 25, 2010·Radiation Protection Dosimetry·E A AinsburyK Rothkamm
Jan 29, 2014·Genome Integrity·Ian M CartwrightTakamitsu A Kato
May 13, 2008·International Journal of Radiation Biology·E Janet TawnHubert Thierens
Nov 2, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Shriram VenkatesanM Prakash Hande
Jul 16, 2010·Risk Analysis : an Official Publication of the Society for Risk Analysis·Linda C Abbott, Andrew D Maynard
Jun 7, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·M HortsmannG Obe
Apr 5, 2016·International Journal of Radiation Biology·E Janet TawnLeanne Hodgson
Nov 5, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Diana PignalosaMarco Durante
Jan 15, 2011·Mutation Research·Megumi HadaFrancis A Cucinotta
Jul 15, 2016·Radiation Protection Dosimetry·G GartyD J Brenner
Sep 13, 2016·Nature Communications·Sam BehjatiPeter J Campbell
Mar 31, 2005·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·E Janet Tawn, Caroline A Whitehouse
Feb 18, 2017·Radiation Research·Guy GartyDavid J Brenner
May 4, 2006·Radiation Research·E Janet TawnAnthony E Riddell
Dec 29, 2020·Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï·I M IlienkoK D Bazyka
Nov 6, 2018·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Adayabalam S Balajee, M Prakash Hande
Jul 8, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Adayabalam S BalajeeCarol J Iddins

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