PMID: 9558711Apr 29, 1998Paper

Stable isotope methodology for kinetic studies of interconversion of cortisol and cortisone in a human subject

Steroids
Y KasuyaT Furuta

Abstract

Oral administration of 5 mg each of deuterium-labeled cortisol ([1,1,19,19,19-2H5]cortisol, cortisol-d5) and cortisone-d5 ([1,1,19,19,19-2H5]cortisone) to a human subject on two different occasions four weeks apart provided a useful means of characterizing the kinetics of the interconversion of cortisol and cortisone. From the data on plasma concentration measurements of cortisol-d5, cortisone-d5, cortisone-5, endogenous cortisol and endogenous cortisone by gas chromatography-mass spectrometry, it was demonstrated that (1) the plasma concentration ratio of cortisone-d5 to cortisol-d5 approached a plateau 4-5 h following either the cortisol-d5 or cortisone-d5 administration and the plateau values for the cortisone-d5 and cortisol-d5 administration were almost identical (about 0.43) and (2) dosing with only 5 mg of the deuterium-labeled steroids suppressed the plasma concentrations of endogenous cortisol and cortisone.

References

Nov 1, 1978·The Journal of Clinical Endocrinology and Metabolism·B L FarissP H Forsham
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Apr 1, 1990·Biomedical & Environmental Mass Spectrometry·H ShibasakiT Hirayama
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Apr 1, 1996·Steroids·F ManteroC H Shackleton

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Citations

Jan 5, 2002·Journal of Chromatography. a·K ShimadaT Higashi
Apr 25, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·T FurutaY Kasuya
Jan 2, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yoshihiko ShinoharaKimiyoshi Ichida
Oct 23, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Takashi FurutaYasuji Kasuya

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