PMID: 16616140DOI: 10.1016/j.febslet.2006.03.054Apr 18, 2006Paper
Stable RNA interference of host thrombospondin-1 blocks Trypanosoma cruzi infection
FEBS Letters
Kaneatra J SimmonsF Villalta
Abstract
Interactions between Trypanosoma cruzi and the extracellular matrix play an important role in cellular invasion. Here we show that T. cruzi increases the levels of thrombospondin-1 (TSP-1) expression in host cells during early infection. Stable RNA interference of host cell TSP-1 knocks down the levels of TSP-1 transcripts and protein expression in mammalian cells causing inhibition of T. cruzi infection. Addition of TSP-1 to these cells restores infection. Thus, host TSP-1, regulated by the parasite, plays a crucial role in early infection. This is the first report showing that a human parasite modulates TSP-1 expression to facilitate infection.
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Citations
Mar 14, 2009·Parasitology Research·Fernando VillaltaHerbert B Tanowitz
Feb 2, 2013·The Journal of Infectious Diseases·Fernando VillaltaGalina I Lepesheva
Jun 23, 2006·Infection and Immunity·Swinburne A J AugustineFernando Villalta
Jul 20, 2007·Infection and Immunity·M Nia MadisonFernando Villalta
Aug 28, 2013·Infection and Immunity·Candice A JohnsonFernando Villalta
Dec 18, 2008·BMC Cell Biology·Carla ClaserMauricio M Rodrigues
Jun 1, 2011·PloS One·Auguste GenovesioLucio H Freitas-Junior
Jul 19, 2012·PloS One·Candice A JohnsonPius N Nde
Nov 13, 2012·PloS One·Gema Martin-MansoDavid D Roberts
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Fernando VillaltaMaria F Lima
Jan 23, 2013·Fish & Shellfish Immunology·Chao LiEric Peatman
Sep 27, 2012·Developmental and Comparative Immunology·Olivier DetournayVirginia M Weis
Mar 7, 2007·Cytokine & Growth Factor Reviews·Wilson SavinoSusana Gea
Nov 28, 2013·Pharmaceuticals·Olivia PerwitasariRalph A Tripp
Sep 18, 2018·PLoS Neglected Tropical Diseases·Shankar SumanPius N Nde
Sep 4, 2007·Reviews in Medical Virology·Luis Isamu Barros KanzakiEnrique R Argañaraz
May 22, 2010·Chemistry & Biodiversity·Pius N NdeFernando Villalta
Jul 16, 2020·International Journal of Molecular Sciences·Ashutosh ArunPius N Nde
Dec 17, 2020·International Journal of Molecular Sciences·Kayla J RayfordPius N Nde
Feb 7, 2020·Developmental and Comparative Immunology·Lauren E FuessLaura D Mydlarz
Jan 6, 2022·PLoS Neglected Tropical Diseases·Ashutosh ArunPius N Nde
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