PMID: 6982908Oct 1, 1982Paper

Stable xenon CT cerebral blood flow measurements computed by a single compartment--double integration model in normal aging and dementia

Journal of Computer Assisted Tomography
T AmanoK F Mortel

Abstract

Programs have been developed, using a single compartmental analysis model, that provide rapid computer derivation for values of both local cerebral blood flows (LCBF) and local tissue: blood partition coefficients (L lambda) using inhaled stable xenon gas (Xes) as the indicator. These programs are planned for utilization of raw data points derived from serial computed tomography scans made between the 3rd and 9th min after 35% Xes inhalation, while concentrations of end-tidal Xes (PEXes) are concurrently monitored. Double integration and least squares fitting permitted estimation of corresponding arterial (assumed from PEXes) and tissue Xes concentrations at each scanning interval during Xes saturation. Derived estimates for L lambda and LCBF values for each region of interest mathematically approximate values saturated to infinity. The method described can be utilized for any freely diffusible indicator. Cross-sectional analysis of results obtained in 13 normal healthy volunteers between 20 and 80 years of age showed no age-related changes in L lambda values but progressive decreases in blood flow of cortex, basal ganglia, and white matter with advancing age. In senile dementia of Alzheimer's type (SDAT, n = 8) L lambda values...Continue Reading

Citations

Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Hoyer
Jan 1, 1996·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·A BartoliniL Sullo
Apr 1, 1985·Journal of Neurosurgery·J S MeyerJ E Rose
Feb 24, 2009·Neurobiology of Aging·Caleb E Finch
Oct 16, 2015·Neurobiology of Aging·Hye-Min KangChan Park
Jul 1, 1987·Brain and Cognition·J S MeyerI Karacan
Nov 1, 1985·Computerized Radiology : Official Journal of the Computerized Tomography Society·Y KitagawaK F Mortel
Oct 1, 1984·Journal of the American Geriatrics Society·W D MacInnesA J Greenhouse
Jun 1, 1985·Journal of the American Geriatrics Society·H TachibanaR L Rogers
Feb 1, 1984·Journal of the American Geriatrics Society·H TachibanaK F Mortel
Apr 1, 1988·Journal of the American Geriatrics Society·S TakedaH Matsui
Oct 1, 1985·Seminars in Nuclear Medicine·H D RoyalB L Holman
Feb 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M D DevousF J Bonte
Mar 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L JunckD A Rottenberg
Dec 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R S HellmanD W Palmer
May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J M DarbyJ Melick
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H YonasC Maxwell
Feb 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T HataF Sakai
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J S MeyerH Tachibana
Nov 1, 1984·Stroke; a Journal of Cerebral Circulation·Y KitagawaR L Rogers
Jan 1, 1984·Stroke; a Journal of Cerebral Circulation·J S MeyerT Okabe
Dec 1, 1989·Stroke; a Journal of Cerebral Circulation·D S DeWittA Marmarou
Feb 1, 1991·Stroke; a Journal of Cerebral Circulation·A HartmannH W Schumacher
Feb 4, 2006·British Journal of Neurosurgery·J HillmanP Mellergård

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