Stachybotrysins A-G, Phenylspirodrimane Derivatives from the Fungus Stachybotrys chartarum

Journal of Natural Products
Jinlian ZhaoJungui Dai

Abstract

Seven new phenylspirodrimane derivatives named stachybotrysins A-G (2-8), together with five known compounds (1, 9-12), were isolated from Stachybotrys chartarum CGMCC 3.5365. Stachybotrysin D (5) is the first reported example of a naturally occurring alcoholic O-sulfation of a phenylspirodrimane, and stachybotrysins F and G (7 and 8) are the first examples possessing an isobenzotetrahydrofuran ring with an acetonyl moiety attached. The structures of these compounds were elucidated on the basis of extensive spectroscopic data analysis and by comparison with reported data. The absolute configurations of 1-8 were determined by X-ray single-crystal diffraction, electronic circular dichroism (ECD), and calculated ECD. Compounds 1 and 8 displayed anti-HIV activity with IC50 values of 15.6 and 18.1 μM, respectively, and 2, 7, 9, and 11 showed inhibitory effect on influenza A virus with IC50 values ranging from 12.4 to 18.9 μM.

References

Jan 1, 1995·Natural Toxins·B B JarvisA Morais
Jan 5, 1999·Bioorganic & Medicinal Chemistry Letters·S B SinghR B Lingham
Dec 29, 2000·Phytochemistry·S F HinkleyB B Jarvis
Apr 4, 2014·Marine Drugs·Bin WuJohannes F Imhoff
Mar 15, 2016·Chembiochem : a European Journal of Chemical Biology·Chang LiIkuro Abe

❮ Previous
Next ❯

Citations

Mar 24, 2018·Natural Product Research·Xin-Hua MaYong-Hong Zhang
Mar 2, 2019·Toxins·Annika JagelsHans-Ulrich Humpf
Nov 19, 2019·Journal of Asian Natural Products Research·Xiao-Na JiaJun-Gui Dai
Aug 12, 2020·Natural Product Reports·Huomiao Ran, Shu-Ming Li
Mar 20, 2018·Mycotoxin Research·Annika JagelsHans-Ulrich Humpf
Jul 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bao-Hui RuanZhong-Tao Ding
Apr 23, 2020·Frontiers in Pharmacology·Emmanuelle LautiéJean A Boutin
Dec 16, 2020·Organic & Biomolecular Chemistry·Minghua JiangSenhua Chen
Sep 2, 2021·Angewandte Chemie·Ying HuangVito Valiante

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.