Stackable Lab-on-Paper Device with All-in-One Au Electrode for High-Efficiency Photoelectrochemical Cyto-Sensing

Analytical Chemistry
Hongmei YangJinghua Yu

Abstract

Highly conductive, robust, and multifunctional integrated paper-supported electrodes are requisite to fulfill the promise of paper-based analytical application. Herein, an all-in-one Au electrode comprising of detection zone, waterproof electronic bridge, and signal output contactor was engineered via combining the double-sided growth method with the secondary wax-printing. Benefiting from the strongly omnidirectional conductivity and desirably mechanical robustness of the as-prepared electrode, a stackable lab-on-paper cyto-device integrated with high-efficiency photoelectrochemical strategy was developed for the MCF-7 cells assay. Specifically, the detection zone of the electrode, serving as the signal generator, was functionalized with a low-toxic cosensitized structure composed of corn-like ZnO nanorods, graphene quantum dots (GQDs), and Ag2Se QDs. With the proximity control of DNA hairpin-based aptamer probe (DHAP), a strong photocurrent could be promoted by the activated cosensitization effect and collected on the signal output contactor via the electron transport of waterproof electronic bridge. Upon the MCF-7 cells recognition, the DHAP switched from closed to open state with the formation of DNA-cell bioconjugates and ...Continue Reading

References

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Citations

Jan 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rudi LiuYingfu Li
Feb 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Linzheng MaJun-Jie Zhu
Aug 12, 2019·Analytical and Bioanalytical Chemistry·Junjun LuoMinghui Yang
Oct 27, 2018·ACS Applied Materials & Interfaces·Dabum KimJungmok You
Jul 10, 2019·Analytical Chemistry·Shasha LiuWei Wang

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