Stage 4 squamous cell carcinoma of the tongue in a child: complete response to chemoradiotherapy

Journal of Pediatric Hematology/oncology
S SoniJ J Beitler

Abstract

This report describes a complete response to a chemoradiotherapy regimen in a child with an advanced and unresectable squamous cell carcinoma of the tongue. An 8-year-old girl had stage 4 squamous cell carcinoma of the tongue (T4N2M0), causing severe trismus and dysphagia. She received hyperfractionated external beam radiotherapy (total 74.4 Gy) and concomitant intravenous infusion of hydroxyurea (0.313 mg/m2 per min) for 43 days. Grade 3 mucositis and myelosuppression were the main toxicities. There was marked symptomatic improvement, and the patient achieved a complete response. She is disease-free 24 months after treatment, and all the acute symptoms have resolved. The regimen was well tolerated with acceptable toxicity and led to a complete objective response. This regimen needs further evaluation to confirm its efficacy and to ascertain its long-term effects in children.

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Citations

Jul 21, 2010·Archives of Otolaryngology--head & Neck Surgery·Luc G T MorrisIan Ganly
Mar 2, 2010·Oral Oncology·Luc G T Morris, Ian Ganly
Sep 12, 2008·The British Journal of Oral & Maxillofacial Surgery·P MehannaB M W Bailey
Jan 16, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·David L BestBrent B Ward

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