Stage-dependent role of growth differentiation factor-9 in ovarian follicle development

Molecular and Cellular Endocrinology
U A Vitt, A J Hsueh

Abstract

GDF-9 was shown to be essential for follicle progression and is the only factor secreted by the oocyte shown to increase the number of primordial and primary follicles in vivo. Furthermore, GDF-9 is a major growth factor involved in the oocyte control of granulosa cell differentiation. A concentration gradient of the paracrine factor GDF-9 established by the oocyte could provide the basis to explain the stratification of granulosa cells in antral and preovulatory follicles. The stimulatory effects of GDF-9 on early follicle development provide a basis for the use of GDF-9 in the treatment of infertility.

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Citations

Apr 20, 2005·Molecular and Cellular Endocrinology·R Kelly Moore, Shunichi Shimasaki
Feb 24, 2006·Biology of Reproduction·Changning YanMartin M Matzuk
Jul 31, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Eric NilssonMichael K Skinner
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Aug 18, 2006·Biology of Reproduction·Makoto OrisakaFumikazu Kotsuji
Oct 30, 2012·Clinical and Experimental Reproductive Medicine·Yong-Pil Cheon
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Jul 14, 2018·International Journal of Molecular Sciences·Shujuan WangGuodong Liu

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