PMID: 11901643Mar 21, 2002Paper

Stage of the epidemic and viral phenotype should influence recommendations regarding mother-to-child transmission of HIV-1

The Lancet Infectious Diseases
C P HudsonA N Smith

Abstract

This article argues for a new approach to use of nevirapine in the prevention of vertical transmission of HIV-1. Existing antenatal surveillance should be strengthened to plan geographical allocation, and subsequent evaluation, of a "nevirapine plus" programme. As the epidemic evolves the programme should also and, ideally, care should be tailored to individual women. Underpinning this approach is evidence that a more virulent viral phenotype appears in many patients with advanced HIV-1 infection. This phenotype will become more common at the population level as the epidemic progresses. As efficacy of zidovudine correlates with viral phenotype, and use of the drug may alter phenotype, there is an urgent need for a replacement that is safe to use with nevirapine.

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Citations

Mar 5, 2003·The Lancet Infectious Diseases·Givans K Ateka
Nov 10, 2013·Risk Analysis : an Official Publication of the Society for Risk Analysis·Heitor de Oliveira DuarteMoacyr Araújo
Feb 1, 2005·The Lancet Infectious Diseases·C P Hudson
Dec 28, 2004·International Journal for Parasitology·Daniel J Salkeld, Lin Schwarzkopf
Dec 4, 2014·Evolutionary Applications·Eric Vander WalFanie Pelletier
May 29, 2009·Journal of the Royal Society, Interface·Sean M MooreParviez R Hosseini
May 29, 2012·Natural Resource Modeling·L J S AllenP van den Driessche
Sep 5, 2012·The Journal of Animal Ecology·Rodrigo K HamedeMenna Jones
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Jun 7, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I ScoonesJ L N Wood
Feb 24, 2012·Proceedings. Biological Sciences·Vincent StaszewskiEmma J A Cunningham
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Jul 2, 2010·Proceedings. Biological Sciences·Eva R KallioOlli Vapalahti
May 14, 2016·Proceedings. Biological Sciences·Elise Mazé-GuilmoGéraldine Loot
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Dec 24, 2014·Ecology and Evolution·Hanna M V Granroth-WildingEmma J A Cunningham

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