Stage pT0 at radical cystectomy confers improved survival: an international study of 4,430 patients

The Journal of Urology
Derya TilkiShahrokh F Shariat

Abstract

We describe the cancer related outcome in patients with pT0 bladder urothelial carcinoma at radical cystectomy who did not receive preoperative chemotherapy in a large multicenter series. We also compared outcomes in patients with pT0 bladder urothelial carcinoma to those in patients with other stages and assessed the effect of clinical stage on outcome. We reviewed the records of 4,430 patients treated with radical cystectomy for bladder urothelial carcinoma without neoadjuvant chemotherapy at 12 centers in the United States, Canada and Europe. Of the patients 228 (5.1%) had pT0 disease at radical cystectomy. Clinical stage was cTa or cTis in 13.6% and cT1 in 29.8% of these patients, and disease was muscle invasive (cT2-4a) in 56.2%. Metastasis developed to regional lymph nodes in 17 cases (7.5%). At a median 48.2-month followup 15 patients (6.6%) had died of bladder cancer. Five-year recurrence-free and cancer specific survival estimates were 89.7% (95% CI 85.3-93.1) and 93.1% (95% CI 88.9-95.6), respectively. Disease-free and cancer specific survival in pT0 cases was similar to that in pTa/pTis cases but significantly better than in pT1 or pT2 cases. On multivariate analysis increased disease recurrence and cancer specific m...Continue Reading

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Citations

Jun 10, 2011·World Journal of Urology·Harun FajkovicShahrokh F Shariat
Oct 11, 2011·World Journal of Urology·Matthias MayMaximilian Burger
Feb 12, 2011·Current Opinion in Oncology·Todd M MorganPeter E Clark
Apr 25, 2013·Oncology Reports·Eric C KauffmanNigel P Mongan
Mar 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H KitamuraUNKNOWN Urologic Oncology Study Group of the Japan Clinical Oncology Group
Aug 13, 2011·Der Urologe. Ausg. A·H Rübben, F Vom Dorp
Apr 24, 2014·Current Urology Reports·Marianne SchmidMichael Rink
Dec 24, 2013·Clinical Genitourinary Cancer·Matthew MossanenJonathan L Wright
Oct 2, 2012·The Journal of Urology·David A GreenShahrokh F Shariat
Jun 18, 2011·The Journal of Urology·Oscar Rodriguez FabaHumberto Villavicencio
Jun 15, 2011·European Urology·Thomas F ChromeckiUNKNOWN Bladder Cancer Research Consortium
Jan 5, 2016·Urologic Oncology·Matthew D Lyons, Angela B Smith
Sep 9, 2015·European Urology·Jakub DobruchStephen A Boorjian
May 20, 2015·Clinical Genitourinary Cancer·Jean Hoffman-Censits, Yu-Ning Wong
Mar 29, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A SoaveM Rink
Jun 4, 2016·Future Oncology·Hristos Z KaimakliotisMichael O Koch
Jul 16, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Evangelos MazarisGregory Boustead
Apr 11, 2012·Nature Reviews. Urology·Ajjai S AlvaArlene O Siefker-Radtke
Dec 20, 2018·Histopathology·Martin J MagersLiang Cheng

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