Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary.

Cell Stem Cell
H R ShcherbataHannele Ruohola-Baker

Abstract

In this study, we uncover a role for microRNAs in Drosophila germline stem cell (GSC) maintenance. Disruption of Dicer-1 function in GSCs during adult life results in GSC loss. Surprisingly, however, loss of Dicer-1 during development does not result in a GSC maintenance defect, although a defect is seen if both Dicer-1 and Dicer-2 function are disrupted. Loss of the bantam microRNA mimics the Dicer-1 maintenance defect when induced in adult GSCs, suggesting that bantam plays a key role in GSC self-renewal. Mad, a component of the TGF-beta pathway, behaves similarly to Dicer-1: adult GSC maintenance requires Mad if it is lost during adult life, but not if it is lost during pupal development. Overall, these results show stage-specific differential sensitivity of GSC maintenance to certain perturbations, and suggest that there may be Dcr-2 dependent redundancy of GSC maintenance mechanisms during development that is lost in later life.

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Citations

Nov 17, 2009·Nature Methods·Carlos M LoyaTudor A Fulga
Apr 27, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Pradeep M JoshiJoel H Rothman
Mar 23, 2011·The EMBO Journal·Annekatrin KönigHalyna R Shcherbata
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Mar 14, 2012·PloS One·Ying Li, Richard W Padgett
Jan 1, 2012·Wiley Interdisciplinary Reviews. Developmental Biology·Xiao Albert Huang, Haifan Lin
May 12, 2015·Nature Communications·Yalan XingHannele Ruohola-Baker
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Apr 3, 2012·Biology of the Cell·Erica Donato Tanaka, Maria-Dolors Piulachs
Jan 18, 2018·BMC Neuroscience·Yongbo Xue, Yong Zhang
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