PMID: 11906920Mar 22, 2002Paper

Stage-specific expression of the intermediate filament protein cytokeratin 13 in luminal epithelial cells of secretory phase human endometrium and peri-implantation stage rabbit endometrium

Biology of Reproduction
Gary E OlsonSubir K NagDas

Abstract

In preparation for blastocyst implantation, uterine luminal epithelial cells express new cell adhesion molecules on their apical plasma membrane. Since one mechanism epithelial cells employ to regulate membrane polarity is the establishment of specific membrane-cytoskeletal interactions, this study was undertaken to determine if new cytokeratin (CK) intermediate filament assemblies are expressed in endometrial epithelial cells during developmental stages related to blastocyst implantation. Type-specific CK antibodies were used for immunocytochemical and immunoblot analyses of 1) intermediate filament networks of the endometrial epithelium during embryo implantation in rabbits and 2) proliferative and secretory phases of the human menstrual cycle. CK18, a type I CK found in most simple epithelia, was expressed in all luminal and glandular epithelial cells of both the human and rabbit endometrium at all developmental stages analyzed; it was also strongly expressed in trophectoderm of the implanting rabbit blastocyst. In contrast, CK13, another type I cytokeratin, exhibited a regulated expression pattern in luminal, but not glandular, epithelial cells of secretory phase human and peri-implantation stage rabbit endometrium. Further...Continue Reading

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Citations

Nov 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Osamu Wada-HiraikeJan-Ake Gustafsson
Apr 12, 2007·Experimental Cell Research·Andrea S OrioloPedro J I Salas
Oct 13, 2006·Journal of Reproductive Immunology·Melinda J JasperSarah A Robertson
Feb 18, 2014·Reproductive Sciences·Amanda N KallenHugh S Taylor
Nov 29, 2017·Journal of Molecular Histology·Nirpesh AdhikariJi-Youn Kim
Jun 10, 2021·Biology of Reproduction·Kailiang LiRomana A Nowak

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