Stage-specific feed intake restriction differentially regulates placental traits and proteome of goats

The British Journal of Nutrition
Qiongxian YanZhiliang Tan

Abstract

A total of twenty-four healthy twin-bearing Liuyang black goats were allocated to two trials. In Trial 1, twelve goats received either the control diet (CG, n 6, 100 % feed) or restricted diet (RG, n 6, 60 % feed of CG) from gestation days 26 to 65 after synchronisation. In Trial 2, the remaining goats were randomly and equally divided into two treatments: CG and RG from days 95 to 125 of gestation. Placental traits, fetal weight, serum parameters, nitric oxide (NO), angiogenesis gene expression and cotyledon proteome were measured at the end of each trial. In early pregnancy, the total and relative weights of placenta, uterine caruncle and cotyledon, as well as fetus, were increased (P<0·05) in RG. The NO content in maternal serum was also increased (P<0·05) in RG. In all, fifty differentially expressed proteins were identified in cotyledon. The up-regulated proteins are related to proliferation and fission of trophoblast cell and the placenta angiogenesis. During the late pregnancy trial, placental weight was increased (P<0·05) in RG, but weight of the fetus was decreased (P<0·05). The capillary density in the cotyledon was also decreased (P<0·01). A total of fifty-eight proteins were differentially expressed in cotyledon. Th...Continue Reading

References

Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Dec 1, 1995·Placenta·R A Ehrhardt, A W Bell
Mar 21, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·J SaarelaT Pihlajaniemi
Apr 18, 1998·Biology of Reproduction·R C GougeY M Huet-Hudson
Apr 1, 1999·Animal Reproduction Science·V E PerryN Phillips
Sep 28, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C SteynM A Hanson
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 7, 2003·Current Pharmaceutical Design·H MaulR E Garfield
Jan 28, 2006·The Journal of Physiology·A L FowdenM Constancia
Nov 3, 2007·Theriogenology·J S Barry, R V Anthony
Dec 25, 2007·Placenta·K Red-Horse
Dec 1, 2002·Nutrition Research Reviews·Alan W Bell, Richard A Ehrhardt
Jan 24, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Dale A RedmerJacqueline M Wallace
Dec 9, 2010·International Journal of Environmental Research and Public Health·Ujjwal K Rout, Julie M Dhossche
Jul 16, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Afsaneh MortezaMahin Bandarian
Jan 2, 2013·Frontiers in Bioscience (Elite Edition)·Haijun GaoChandra Yallampalli
Jan 19, 2016·Journal of Molecular Histology·Hércules Jonas RebelatoRosana Catisti
Feb 29, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chengjian LiZhiliang Tan

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Citations

Jan 20, 2020·Analytical Biochemistry·M A El-SamahyFeng Wang

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