Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum.

Parasitology Research
N Kumar, H Zheng

Abstract

Qinghaosu, an anti-malaria drug, has been found to kill not only asexual blood stages but also the early stages of gametocytes of Plasmodium falciparum. The effect of qinghaosu in vitro depends on the concentration of the drug as well as on the initial parasitemia level (IC50 = 10-20 nM with 1% initial parasitemia). Resistance of P. falciparum to other anti-malaria drugs, e.g., chloroquine and pyrimethamine, did not affect susceptibility of its asexual and sexual stages to qinghaosu. Gametocytocidal effect of qinghaosu may play a role in the interruption of malaria transmission.

References

Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·M E Smalley
Dec 1, 1979·Antimicrobial Agents and Chemotherapy·R E DesjardinsJ D Chulay
Oct 1, 1979·Parasitology·R E Sinden, M E Smalley
Aug 20, 1976·Science·W Trager, J B Jensen
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·S WakiM Y Zhu
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·A N ChawiraW Peters
May 1, 1985·The American Journal of Tropical Medicine and Hygiene·J B JiangM Aikawa
Aug 7, 1982·Lancet·J B JiangK Arnold
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·Z L LiW Peters
Nov 26, 1981·Nature·T Ifediba, J P Vanderberg

❮ Previous
Next ❯

Citations

Aug 5, 1994·Pharmacy World & Science : PWS·H J WoerdenbagC B Lugt
Jun 1, 1996·General Pharmacology·S Kamchonwongpaisan, S R Meshnick
Nov 19, 2002·International Journal for Parasitology·Steven R Meshnick
Nov 18, 1997·International Journal for Parasitology·G A Butcher
May 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·S L FleckR E Sinden
Mar 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·N N LeP A Kager
Jan 16, 2004·Lancet·Patrick E Duffy, Theonest K Mutabingwa
Aug 21, 2013·Parasitology·Alice S ButterworthKatharine R Trenholme
Jun 15, 2013·The Journal of Infectious Diseases·Nicholas M DouglasRic N Price
Sep 28, 2012·Proceedings. Biological Sciences·Petra SchneiderSarah E Reece
Jun 15, 2007·Antimicrobial Agents and Chemotherapy·Marcel KaiserJonathan L Vennerstrom
May 1, 2013·Antimicrobial Agents and Chemotherapy·Michael J DelvesRobert E Sinden
Mar 30, 2004·Antimicrobial Agents and Chemotherapy·Sasithon PukrittayakameeNicholas J White
Feb 11, 2005·Postgraduate Medical Journal·C J WoodrowS Krishna
Nov 4, 2008·Malaria Journal·Wirichada PongtavornpinyoNicholas J White
Feb 1, 1993·Japanese Journal of Medical Science & Biology·N Mehra, V K Bhasin
Feb 25, 2014·Parasitology Research·Rashad Abdul-GhaniAhmed A Azazy
Jun 9, 2011·Drug and Chemical Toxicology·Mosebolatan V FafoworaOchuko L Erukainure
Feb 4, 2016·Parasite : Journal De La Société Française De Parasitologie·Abdoulaye A DjimdeOgobara K Doumbo
Sep 21, 2010·International Journal of Antimicrobial Agents·Florian AstelbauerJulia Walochnik
Aug 15, 2006·Tropical Medicine & International Health : TM & IH·Ian M Hastings
Sep 13, 2014·Tropical Medicine & International Health : TM & IH
Oct 27, 2015·Science China. Life Sciences·Bing Zhou
Aug 27, 2002·Annals of Tropical Medicine and Parasitology·D J FryauffJ K Baird
Oct 29, 2014·Antimicrobial Agents and Chemotherapy·Anusha M Gopalakrishnan, Nirbhay Kumar
Apr 13, 2010·Molecular and Biochemical Parasitology·David A Baker
Sep 30, 2014·FEBS Letters·Amornrat Naranuntarat JensenLaran T Jensen
Mar 8, 2013·Travel Medicine and Infectious Disease·Tomas Jelinek
Sep 7, 2011·Memórias do Instituto Oswaldo Cruz·Grace Olusola GbotoshoElsie Olufunke Adewoye
Jan 6, 2001·Memórias do Instituto Oswaldo Cruz·E M Riley
Apr 13, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew M IppolitoPhilip J Rosenthal
Sep 29, 2006·International Journal for Parasitology·Jacob GolenserGeorges E Grau

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.