PMID: 8609148Jan 1, 1996Paper

Stage-specific gene expression during hepatocarcinogenesis in the rat

Journal of Cancer Research and Clinical Oncology
H C Pitot

Abstract

The alteration of genetic expression ubiquitously seen in both preneoplastic and neoplastic tissues has been investigated for many years in the hope that the critical molecular changes resulting in cancer can be elucidated. The alteration of the expression of specific genes has already been employed in diagnostic and even screening procedures for this disease. In the past many observations of such alterations have led to a variety of theories but not definitive generalizations. Studies of the alteration of genetic expression may now be viewed in the light of our understanding of the multistage nature of neoplastic development. This brief review describes a number of genes the expressions of which are altered during the stages of initiation and promotion, in contrast to the alteration of expression of genes during the stage of progression. The promotion stage is concerned primarily with the chronic interaction of promoting agents in the environment with the genetic apparatus of the cell, played out on the altered genetic background resulting from the stage of initiation. In contrast, the progression stage is characterized primarily by an evolving karyotypic instability resulting in continual genetic changes during this stage. On...Continue Reading

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Citations

Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H E Van GijsselJ H Meerman
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y DraganM Pastor-Anglada
Sep 12, 2009·Critical Reviews in Toxicology·Annie M JarabekErrol Zeiger
Sep 24, 2009·Environmental and Molecular Mutagenesis·L M SargentS H Reynolds
Mar 21, 2008·International Journal of Cancer. Journal International Du Cancer·Yanting QiLihui Lai
Apr 8, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mohamed A Radwan, Ahmed K Salama
Dec 20, 2011·Mutation Research·L M SargentS H Reynolds
Apr 27, 2005·Psycho-oncology·Christina D WagnerAnna Maria Storniolo
Jul 9, 2005·Expert Review of Anticancer Therapy·Victor Cohen, Fadlo R Khuri
Oct 12, 2010·Nanotoxicology·Linda M SargentVincent Castranova
Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·L Magnelli, V Chiarugi

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