Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins

The Journal of Immunology : Official Journal of the American Association of Immunologists
S GuptaA B Pernis

Abstract

Optimal humoral responses depend on the activation of Ag-specific B cells, followed by their progression toward a fully differentiated phenotype. Acquisition of stage-appropriate patterns of gene expression is crucial to this differentiation program. However, the molecular mechanisms used by B cells to modulate gene expression as they complete their maturation program are poorly understood. IFN-regulatory factor 4 (IRF-4) plays a critical role in mature B cell function. Using the transcriptional regulation of the human B cell activation marker CD23 as a model system, we have previously demonstrated that IRF-4 is induced in response to B cell-activating stimuli and that it acts as a transactivator of CD23 gene expression. We have furthermore found that IRF-4 function can be blocked by B cell lymphomas 6 (BCL-6) protein, a Krüppel-type zinc finger repressor normally expressed in germinal center B cells. However, CD23 expression is known to be down-regulated in plasma cells despite high level expression of IRF-4 and the lack of BCL-6, suggesting that in plasma cells the IRF-4-mediated induction of CD23 is prevented by its interaction with a distinct repressor. In this set of studies, we demonstrate that IRF-4 interacts with B lymp...Continue Reading

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Citations

Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alessandra B Pernis
Jan 30, 2003·Oncogene·Olivier Albagli-Curiel
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ildikó GyöryKenneth L Wright
May 4, 2005·The Journal of Experimental Medicine·Lynn M CorcoranPhilip D Hodgkin
Jun 24, 2006·Journal of Cellular Biochemistry·Yasuhiro NakayamaSherman M Weissman
Nov 6, 2007·Statistics in Medicine·Wei ChenDaniel J Sargent
Jun 21, 2006·Nature Immunology·Simon Fillatreau, Andreas Radbruch
Jan 10, 2012·Annual Review of Immunology·Arthur L ShafferLouis M Staudt
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giorgio CattorettiBachir Alobeid
Jan 14, 2003·Annual Review of Immunology·Kathryn L CalameChainarong Tunyaplin
Oct 11, 2002·The Journal of Biological Chemistry·Chuan-Min HuAlessandra B Pernis
Feb 5, 2003·The Journal of Experimental Medicine·Jessica C FanzoAlessandra B Pernis
Nov 29, 2001·Nature Immunology·K L Calame
Apr 17, 2012·Immunological Reviews·Nilushi S De SilvaUlf Klein
Oct 27, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Cathrine K FogAnders H Lund
Apr 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arthur L ShafferLouis M Staudt
Jun 7, 2012·Development·Tobias Hohenauer, Adrian W Moore
Apr 28, 2004·Developmental Biology·Chiou-Hwa YuhEric H Davidson
Feb 8, 2005·Biochemical and Biophysical Research Communications·Takashi KusunokiAkira Shimizu
Dec 17, 2008·Experimental Cell Research·Shinu A John, Lee Ann Garrett-Sinha

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