PMID: 8604560Nov 1, 1995Paper

Stages of Marek's disease virus latency defined by variable sensitivity to interferon modulation of viral antigen expression

Veterinary Microbiology
L M VolpiniP I Marcus

Abstract

Cytokines in conditioned medium can suppress expression of viral internal antigens (VIA) in lymphocytes latently infected with Marek's disease virus. In the present study, conditioned media produced by spleen cells stimulated with concanavalin A or by mixed-lymphocyte reaction had significantly greater (P < 0.05) VIA-suppressive activity with lymphocytes harvested from birds at 14 days post infection than with those collected at 7 days. This finding defines two stages during the latent period in which sensitivity of lymphocytes to cytokine modulation of viral expression differs. Suppression involved proteins representing immediate-early, early and late viral antigens. Physico-chemical characterization of the suppressive factor in conditioned medium was consistent with that expected of interferon. Indeed, natural interferon prepared from avian reovirus-exposed chicken embryo cells, and recombinant chicken interferon, both mimicked the activity of conditioned medium and were more suppressive with lymphocytes from the later stage of latency.

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Citations

Mar 16, 2000·Developmental and Comparative Immunology·K A Schat, Z Xing
Jun 29, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K W JarosinskiK A Schat
Apr 25, 2008·Viral Immunology·Mohammad HeidariShayan Sharif
May 17, 2011·PLoS Pathogens·William N MwangiAdrian L Smith
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·H C LiuH H Cheng
Jun 23, 2004·Veterinary Immunology and Immunopathology·B J G BaatenT F Davison
Sep 19, 2003·The Journal of General Virology·Alexander D BarrowVenugopal K Nair

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