PMID: 16536975Mar 16, 2006Paper

Staging 915 cases of nasopharyngeal carcinoma after simple radical radiotherapy (Part II)--Checkout of AJCC/UICC staging system (1997)

Ai zheng = Aizheng = Chinese journal of cancer
Jian-Ming GaoFang-Yun Xie

Abstract

On the basis of our previous research, this study was to validate the rationality of AJCC/UICC staging system (1997) of nasopharyngeal carcinoma (NPC), and to provide some suggestions. Survival data of 915 NPC patients, received radical radiotherapy alone in Cancer Center of Sun Yat-sen University from Jan. 1997 to Dec. 1998, were analyzed with Life table, Cox regression, Kaplan-Meier, and log-rank methods. Cox regression analysis showed that the 5-year survival rate of the 915 patients was significantly correlated to their age and tumor stage classified according to AJCC/UICC (1997) staging system; while that of the 803 patients no more than 60 years old was only significantly correlated to tumor stage. Life table analysis validated that the tumor stage classified according to AJCC/UICC staging system can roughly predict the prognosis, but the differences between stage I and IIa, or IVa and IVb were not significant. Kaplan-Meier analysis showed no significant differences of survival rate between stage T1 and T2a, or T3 and T4 when adjusted by N classification, and between stage N2 and N3a, or N3a and N3b when adjusted by T classification. Therefore, we adjusted stage T2a to T1, stage N1 with inferior cervical nodes metastasis ...Continue Reading

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