Staging accuracy of ampullary tumors by endoscopic ultrasound: meta-analysis and systematic review

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society
Guru TrikudanathanAasma Shaukat

Abstract

Accurate preoperative staging of ampullary neoplasms is of paramount importance in predicting prognosis and determining the most appropriate therapeutic approach. The aim of the present review was to evaluate the accuracy of endoscopic ultrasound (EUS) in predicting depth of ampullary tumor invasion (T-stage) and regional lymph node status (N-stage) by carrying out a meta-analysis of all relevant studies. We systematically searched PubMed, Medline and Scopus databases for all studies published between January 1980 and December 2012. Only EUS studies involving ≥ 10 patients with ampullary neoplasms, confirmed by surgical histopathology, with data available for construction of a 2 × 2 table were included. Meta-analysis of 14 studies involving 422 patients using the Mantel-Haenszel method was performed. Pooled sensitivity and specificity of EUS to diagnose T1-stage tumor were 77% (95% CI: 69-83) and 78% (95% CI: 72-84), respectively. Pooled sensitivity for T4 tumors was 84% (95% CI: 73-92) and specificity was 74% (95% CI: 63-83). Combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio for diagnosing nodal status were 0.70 (95% CI: 0.62-0.77), 0.74 (95% CI: 0.67-0.0.80), 2.4...Continue Reading

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Citations

Oct 9, 2014·Gastrointestinal Endoscopy·Wiriyaporn RidtitidGregory A Coté
May 18, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Jesús EspinelMaría Guerra Del Río
Mar 6, 2019·Journal of Digestive Diseases·Chun Yan PengXiao Ping Zou
May 10, 2020·Expert Review of Gastroenterology & Hepatology·Kenjiro YamamotoTakao Itoi
Aug 3, 2020·Current Opinion in Gastroenterology·Jagpal S KlairRichard Kozarek
Jun 9, 2018·United European Gastroenterology Journal·Kwang Hyun ChungYong-Tae Kim
Mar 7, 2020·Scientific Reports·Eloy TaglieriJosé Celso Ardengh
May 13, 2021·Journal of Surgical Oncology·Akira WatanabeKen Shirabe
Feb 5, 2021·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Pietro GambittaMaurizio Vertemati

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