Staging disease severity in movement disorder tauopathies: brain atrophy separates progressive supranuclear palsy from corticobasal degeneration

Movement Disorders : Official Journal of the Movement Disorder Society
Emma C SchofieldGlenda M Halliday

Abstract

The movement disorders progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) both deposit tau in degenerating neurons and are considered to be tauopathies. The recently developed scheme for staging tissue degeneration in another tauopathy, frontotemporal dementia [Broe et al., Neurology 2003;60:1005-1011] was applied to pathologically confirmed PSP (n = 24) and CBD (n = 9) cases and correlated with clinical indices. In contrast to frontotemporal dementia, the majority of PSP cases had limited or no visible atrophy, while the pattern of atrophy in CBD cases conformed to the existing staging scheme (all but one case exhibiting substantial visible tissue atrophy). Despite similar clinical severity and disease duration between groups, there was a marked difference between the PSP and CBD cases in pathological disease stage (chi(2) = 8.86; P = 0.03). The degree of global atrophy in PSP appears to be distinct from other tauopathies, while CBD fits the same pattern as other pathological forms of frontotemporal dementia.

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Citations

May 10, 2011·Journal of Molecular Neuroscience : MN·Jillian J Kril, Glenda M Halliday
Mar 10, 2007·Brain : a Journal of Neurology·Jennifer L WhitwellKeith A Josephs
May 3, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Maria StamelouKailash P Bhatia
Jul 6, 2010·The European Journal of Neuroscience·Federica AgostaMassimo Filippi
Sep 14, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·M B AertsM M Verbeek
Mar 18, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Emma C SchofieldGlenda M Halliday
Jan 27, 2017·Brain : a Journal of Neurology·Luca PassamontiJames B Rowe
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Dec 7, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Juliane WinkelmannBertram Müller-Myhsok
Apr 1, 2017·Translational Neurodegeneration·Usman SaeedMario Masellis
Apr 5, 2018·Current Neurology and Neuroscience Reports·Christine Ghadery, Antonio P Strafella
May 21, 2019·Frontiers in Molecular Neuroscience·Eftychia VasiliTiago Fleming Outeiro
Nov 13, 2020·Frontiers in Neurology·Usman SaeedMario Masellis
Jun 2, 2021·Journal of Movement Disorders·Hee Kyung ParkIrene Litvan

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