Stalking intermediates in oxygen activation by iron enzymes: motivation and method

Journal of Inorganic Biochemistry
J Martin Bollinger, Carsten Krebs

Abstract

The study of high-valent-iron enzyme intermediates began in the mid-1900s with the discovery of compounds I (or ES) and II in the heme peroxidases, progressed to non-heme-diiron enzymes in the 1990s with the detection and characterization of the Fe(III)-Fe(IV) complex, X, and the Fe(IV)-Fe(IV) complex, Q, in O(2) activation by ribonucleotide reductase R2 (RNR-R2) and soluble methane monooxygenase (sMMO), respectively, and was most recently extended to mononuclear non-heme-iron oxygenases with the trapping and spectroscopic characterization of the Fe(IV)-oxo intermediate, J, in the reaction of taurine:alpha-ketoglutarate dioxygenase (TauD). Individually, each of these landmark studies helped reveal the chemical logic of that particular enzyme system. Collectively, they have significantly advanced our understanding of Nature's strategies for oxidative transformation of biomolecules (both natural and "xenobiotic"). With high-valent complexes now having been described in representatives of three major classes of iron enzymes, it is an appropriate time to ask whether and what additional insights might be gleaned from further stalking of related intermediates in other systems. In this review, we advocate that there is still much to b...Continue Reading

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Citations

Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lee M HoffartCarsten Krebs
Jun 5, 2007·Accounts of Chemical Research·Carsten KrebsJ Martin Bollinger
Mar 14, 2009·Journal of the American Chemical Society·Jorge Alex Pavon, Paul F Fitzpatrick
Nov 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kevin P McCusker, Judith P Klinman
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael M MbughuniJohn D Lipscomb
Sep 9, 2011·Journal of the American Chemical Society·Genqiang XueLawrence Que
Feb 7, 2012·Biochemistry·Laura M K DassamaJ Martin Bollinger
Feb 13, 2013·The Journal of Biological Chemistry·Kajsa G V SigfridssonMichael Haumann
Jan 12, 2010·Antioxidants & Redox Signaling·Lars M BlankBruno Bühler
Feb 10, 2016·The Journal of Physical Chemistry. a·Anna WójcikTomasz Borowski
Apr 14, 2009·Current Opinion in Chemical Biology·J Martin Bollinger, Joan B Broderick
Sep 16, 2010·The FEBS Journal·Emily FlashmanChristopher J Schofield
Aug 19, 2015·Applied Microbiology and Biotechnology·Filipe FolgosaAlice S Pereira
Feb 4, 2012·The Biochemical Journal·Davide PapaleSimon Daff
May 20, 2016·Journal of the American Chemical Society·Esta TamanahaCarsten Krebs
Oct 30, 2016·Biochemistry·Edward I SolomonKyle D Sutherlin
Jan 17, 2017·Journal of the American Chemical Society·Spencer C PeckWilfred A van der Donk
Jan 27, 2017·Journal of the American Chemical Society·Erik AndrisJana Roithová
Jan 17, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yongho KimSumin Park
Jul 19, 2018·Angewandte Chemie·Johannes E M N Klein, Gerald Knizia
Jan 16, 2007·Nature Chemical Biology·Danica P GalonićCarsten Krebs
Nov 21, 2007·Chemical Communications : Chem Comm·Crisjoe A Joseph, Michael J Maroney
May 9, 2008·Chemical Communications : Chem Comm·Xiaopeng Shan, Lawrence Que
Feb 25, 2009·Photosynthesis Research·Carsten Krebs, J Martin Bollinger
Oct 31, 2009·Chemistry : a European Journal·Olga V MakhlynetsLawrence Que
Dec 1, 2010·Chemistry : a European Journal·Olga V Makhlynets, Elena V Rybak-Akimova
Apr 8, 2014·The Journal of Biological Chemistry·Warintra PitsawongAnne-Frances Miller
Sep 11, 2020·Chemical Communications : Chem Comm·Lorenzo D'AmoreMarcel Swart

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