PMID: 8597913Dec 1, 1995Paper

Standard and higher doses of atropine in a canine model of pulseless electrical activity

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
D J DeBehnkeT P Aufderheide

Abstract

To determine whether standard or increased doses of atropine improve the return of spontaneous circulation (ROSC) rate in a canine model of pulseless electrical activity (PEA). A prospective, controlled, blinded laboratory investigation was performed using an asphyxial canine cardiac arrest model. After the production of asphyxial PEA, 75 dogs remained in untreated PEA for 10 minutes and then were randomized to receive placebo (group 1) or one of four doses of atropine (group 2, 0.04 mg/kg; group 3, 0.1 mg/kg; group 4, 0.2 mg/kg; group 5, 0.4 mg/kg). All the animals received mechanical external CPR and epinephrine (0.02 mg/kg every 3 minutes) throughout resuscitation. The ROSC rates were not significantly different between the groups (group 1, 73%; group 2, 67%; group 3, 40%; group 4, 47%; group 5, 27%; p = 0.06). The heart rates and hemodynamics during resuscitation were not significantly different between the groups. In this canine model of asphyxial PEA cardiac arrest, standard-dose atropine did not improve ROSC rates, compared with placebo. Increasing doses of atropine tended to decrease ROSC rates, compared with placebo and standard-dose atropine.

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Citations

Feb 22, 2008·Journal of Veterinary Internal Medicine·S J Plunkett, M McMichael
Jan 15, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN Survey of Survivors After Out-of-hospital Cardiac Arrest in KANTO Area, Japan (SOS-KANTO) Study Group
Feb 16, 2012·Journal of the American Veterinary Medical Association·Manuel BollerCynthia M Otto
Aug 18, 2016·European Heart Journal. Cardiovascular Pharmacotherapy·Andreas LundinPeter Lundgren
Aug 3, 2012·Journal of Veterinary Emergency and Critical Care·Elizabeth A RozanskiUNKNOWN RECOVER Advanced Life Support Domain Worksheet Authors
Jun 15, 2012·Journal of Veterinary Emergency and Critical Care·Daniel J FletcherUNKNOWN Veterinary Emergency and Critical Care Society
Sep 29, 2012·Journal of Veterinary Emergency and Critical Care·Barbara L Maton, Sean D Smarick
Dec 1, 1995·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·J M Christenson
Feb 1, 1997·Pediatric Clinics of North America·H M Ushay, D A Notterman

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