PMID: 28102Jul 1, 1978

Standard and long-acting depot neuroleptics in chronic schizophrenics: an 18-month open multicentric study

Archives of General Psychiatry
P SimonP Péron-Magnan

Abstract

The overall objective of this 18-month open study was to compare standard neuroleptics and long-acting depot neuroleptics following the current psychiatric practice in order to determine the best therapy. Thirty French psychiatrists from 15 different wards participated in this experiment. One hundred eighty-one chronic schizophrenic patients were randomly assigned to receive one of the following three treatments: standard neuroleptics, pipotiazine palmitate, or fluphenazine decanoate. Criteria used for evaluation were an overall clinical evaluation by a psychiatrist, a Brief Psychiatric Rating Scale, and a Nurse's Observation Scale for Inpatient Evaluation. No significant difference (P greater than .05) was observed between the three groups in drug effectiveness or tolerance.

Citations

May 1, 1979·Psychological Medicine·J LevineG B Cassano
Oct 21, 2004·The Cochrane Database of Systematic Reviews·M DineshSeema N Quraishi
Jun 11, 2014·The Cochrane Database of Systematic Reviews·Jataveda MahapatraClive E Adams
Feb 6, 2015·The Cochrane Database of Systematic Reviews·Nicola MaayanClive E Adams

Related Concepts

Controlled-Release Preparations
Lyogen
Factor Construct Rating Scales (Fcrs)
Schizophrenia
Individual Adjustment
Thiazines
Antipsychotic Effect

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