Standard pharmacological treatment and new therapies for overactive bladder

Urologia
Giulio Del PopoloVincenzo Li Marzi

Abstract

The prevalence of overactive bladder (OAB) in adult males varies from 10.2% to 17.4%, and in females from 7.7 to 31.3. 16.5% of the adult population presents symptoms consistent with OAB; of these, 37.2% are actually affected. The OAB has a significant effect on the quality of life. Initial treatment includes behavioral therapy, physiotherapy and antimuscarinic drugs. In patients where behavioral modifications fail, treatment is associated with antimuscarinics. The antimuscarinic agents used to treat OAB showed some efficacy, but adverse events too, such as dry mouth, constipation, headache and blurred vision. In selected cases unresponsive to antimuscarinic therapy, it is possible to use second-line treatments represented by sacral neuromodulation and botulinum toxin type A both for idiopathic detrusor overactivity, where it is still an experimental treatment, and for neurogenic cases with 2011 FDA approval. Surgical options represent the last choice for selected cases.

References

Jun 1, 1986·Journal of Autonomic Pharmacology·C A Maggi, A Meli
Aug 1, 1989·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·A HarunoM Iriki
Oct 1, 1988·British Journal of Urology·R J BaigrieA W Pengelly
Jun 9, 1998·Drugs·C J HillsJ A Balfour
Oct 17, 1998·World Journal of Urology·J W ThüroffE A Tanagho
Oct 26, 1999·The Annals of Pharmacotherapy·J M Ruscin, N E Morgenstern
Jun 6, 2000·International Journal of Clinical Pharmacology and Therapeutics·I Füsgen, D Hauri
Mar 15, 2001·Urology·P Van KerrebroeckUNKNOWN Tolterodine Study Group
Feb 1, 2003·Urology·Paul AbramsUNKNOWN Standardisation Sub-Committee of the International Continence Society
Jun 18, 2003·World Journal of Urology·W F StewartA J Wein
Nov 19, 2003·Current Urology Reports·Scott A MacDiarmid
Nov 17, 2004·Scandinavian Journal of Urology and Nephrology. Supplementum·Lori Birder
Jun 14, 2006·Current Opinion in Urology·Floor van der PalBart L H Bemelmans
Sep 8, 2006·BJU International·Anco C Van VoskuilenPhilip E V A van Kerrebroeck
Jul 25, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Kumiko KatoMomokazu Gotoh
Sep 18, 2007·The Journal of Urology·Philip E V van KerrebroeckUbi van den Hombergh
Jan 22, 2008·European Urology·Giulio Del Popolo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.