Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis

The Cochrane Database of Systematic Reviews
Valerie Waters, Felix Ratjen

Abstract

The antibiotics used to treat pulmonary infections in people with cystic fibrosis are typically chosen based on the results of antimicrobial susceptibility testing performed on bacteria traditionally grown in a planktonic mode (grown in a liquid). However, there is considerable evidence to suggest that Pseudomonas aeruginosa actually grows in a biofilm (or slime layer) in the airways of people with cystic fibrosis with chronic pulmonary infections. Therefore, choosing antibiotics based on biofilm rather than conventional antimicrobial susceptibility testing could potentially improve response to treatment of Pseudomonas aeruginosa in people with cystic fibrosis. This is an update of a previously published Cochrane Review. To compare biofilm antimicrobial susceptibility testing-driven therapy to conventional antimicrobial susceptibility testing-driven therapy in the treatment of Pseudomonas aeruginosa infection in people with cystic fibrosis. We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and handsearching of journals and conference abstract books. We also searched a registry of ongoing trials and the reference lists of relevant articles and reviews.Most recent search: 19 Nove...Continue Reading

Citations

Oct 6, 2017·The Cochrane Database of Systematic Reviews·Valerie Waters, Felix Ratjen
Jun 11, 2020·The Cochrane Database of Systematic Reviews·Sherie SmithFelix Ratjen
Oct 4, 2017·NPJ Biofilms and Microbiomes·Mathias MüskenSusanne Häussler
Jan 10, 2020·BioMed Research International·Miguel Ángel Pacha-OlivenzaAmparo M Gallardo-Moreno

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